Correlation between tumor markers and tumor size.
Correlation between tumor markers and tumor size.
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发表时间：
1987
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通讯作者：
T. Kobayashi
中科院分区：
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作者：
T. Kobayashi
传统上，肿瘤的诊断是通过组织病理学进行的，因为肿瘤标志物的特异性不够，并且仅观察到低阳性率。为了诱导肿瘤标志物自由释放到血液中，IM注射维生素A和红外线热疗用于203名癌症患者。定期采血测定血清CEA、铁蛋白（FT）、甲胎蛋白、唾液酸及铁蛋白/血清铁（FT/Fe）比值。对每种释放的肿瘤标志物的分析导致阳性解释率增加，表明肿瘤标志物与肿瘤大小之间存在线性相关性。作为使用释放诱导的肿瘤标志物的组合测定的评价结果，五种标志物中的任何三种的阳性病例的比率与肿瘤大小的增加相关地增加至53%、65%和94%。
Traditionally diagnosis of tumors is made by histopathology, because tumor markers are not sufficiently specific, and only low rates of positive cases have been observed. To induce free release of tumor markers into the blood, the IM injection of vitamin A and infrared-ray hyperthermia was used in 203 cancer patients. Blood samples were collected periodically to determine the levels of CEA, ferritin (FT), alpha-fetoprotein, sialic acid, and the ratio of ferritin to serum iron (FT/Fe). The analysis of each released tumor marker led to an increase in the rate of positive interpretations, indicating a linear correlation between tumor marker and tumor size. As a result of the evaluation of a combination assay of tumor markers using release induction, the rates of positive cases for any three of five markers were increased to 53, 65, and 94% in correlation with an increase in tumor size.