Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?
Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?
复制标题
症状出现的年龄与成人强迫症患者记忆障碍的严重程度是否相关？
DOI：
10.1176/appi.ajp.158.1.137
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Jenike,MA
中科院分区：
文献类型：
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作者：
Henin,A;Savage,CR;Rauch,SL;Deckersbach,T;Wilhelm,S;Baer,L;Otto,MW;Jenike,MA
发病年龄是强迫症（OCD）神经生物学特征的一个潜在的重要标志。本研究探讨了症状发作年龄与成人强迫症记忆损害的关系。方法作者采用Rey-Osterrieth复杂图形测验和加州言语学习测验比较了37例成人强迫症患者的记忆功能（发病年龄小于18岁）与31例成人-两组之间在任何语言和非语言记忆测量上没有发现差异。根据先前发现的对强迫症的额-纹状体系统功能障碍和损伤敏感的测试，症状发作时的年龄与强迫症成年患者的记忆表现无关。这种功能障碍似乎是成人强迫症的一贯特征，无论最初症状发作的年龄如何。
OBJECTIVEAge at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD.METHODThe authors used the Rey-Osterrieth Complex Figure Test and the California Verbal Learning Test to compare memory functioning of 37 adult OCD patients with self-reported childhood onset of symptoms (onset at less than 18 years of age) with that of 31 patients with adult-onset symptoms.RESULTSNo differences were found between the two groups on any of the verbal and nonverbal memory measures.CONCLUSIONSSelf-reported age at symptom onset is not associated with memory performance in adult patients with OCD according to tests previously found to be sensitive to frontal-striatal system dysfunction and impairment in OCD. Such dysfunction appears to be a consistent feature of OCD in adults, regardless of age at initial symptom onset.