Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune ModulatorNovel Insights from Knockout Mice
Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune ModulatorNovel Insights from Knockout Mice
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DOI：
10.1089/dna.2016.3472
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发表时间：
2016-10-01
影响因子：
3.1
通讯作者：
Myal, Yvonne
中科院分区：
文献类型：
--
作者：
Ihedioha, Olivia C.;Shiu, Robert P. C.;Myal, Yvonne
乳腺癌在患者中引发免疫应答的倾向是公认的。原发性乳腺肿瘤内肿瘤浸润淋巴细胞的积累与更好的预后和对治疗的更好反应有关。催乳素诱导蛋白（PIP）是一种在乳腺生理条件下表达的分子量为15kD的蛋白质，被认为是乳腺分化的标志物。虽然PIP在包括乳腺癌在内的乳腺病理条件下高度表达，但在极少数其他癌症中表达。尽管PIP的功能尚未完全阐明，但大量研究表明其主要作用可能与宿主防御和免疫调节有关。然而，没有证据表明PIP和免疫反应之间存在直接联系。在这篇综述中，我们讨论了我们最近的工作与PIP缺陷小鼠，连接PIP不仅在先天免疫中的作用，但第一次，提供证据的作用，在细胞介导的免疫。这些在Pip敲除小鼠中的功能研究为PIP在免疫中的作用提供了新的见解，并表明PIP可能在乳腺癌中发挥类似的免疫调节作用。
The propensity for breast cancers to elicit immune responses in patients is well established. The accumulation of tumor infiltrating lymphocytes within the primary breast tumor has been linked to better prognosis and better response to therapy. The prolactin-inducible protein (PIP) is a 15kD protein that is expressed under physiological conditions of the breast and is regarded as a marker of mammary differentiation. While highly expressed under pathological conditions of the mammary gland, including breast cancers, PIP is expressed in very few other cancers. Although the function of PIP is not well elucidated, numerous studies suggest that its primary role may be related to host defense and immune modulation. However, evidence to show a direct link between PIP and the immune response has been lacking. In this review, we discuss our recent work with Pip-deficient mice, linking PIP not only to a role in innate immunity but for the first time, providing evidence for a role in cell-mediated immunity. These functional studies in Pip null mice lend new insight into the role of PIP in immunity and suggest that PIP may play a similar immune-regulatory role in breast cancer.