Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1.
Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1.
复制标题
黄曲霉毒素 B1 抑制盐诱导的 B-DNA 向 Z-DNA 的转化。
作者：
A. Nordheim;W. Hao;G. Wogan;A. Rich
The carcinogen aflatoxin B1 was reacted with a polymer of alternating deoxyguanine and deoxycytosine residues to determine the effect that adduct formation has on the conversion of this polymer from the right-handed B-DNA form found at low salt concentrations to the left-handed Z-DNA form found at high salt concentrations. Reaction with aflatoxin strongly inhibited the salt-induced conversion of this polymer from B-DNA to Z-DNA. This inhibition could be detected even at relatively low binding levels.
