INTERNATIONAL RENAL-CELL CANCER STUDY .1. TOBACCO USE
INTERNATIONAL RENAL-CELL CANCER STUDY .1. TOBACCO USE
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DOI：
10.1002/ijc.2910600211
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发表时间：
1995-01-17
影响因子：
6.4
通讯作者：
ADAMI, HO
中科院分区：
文献类型：
--
作者：
MCLAUGHLIN, JK;LINDBLAD, P;ADAMI, HO
一项国际、多中心、基于人群的病例对照研究调查了肾细胞癌 (RCC) 与吸烟之间的关系。澳大利亚、丹麦、德国、瑞典和美国使用共享方案和调查问卷进行了协调研究。该研究共采访了 1,732 名病例（1,050 名男性，682 名女性）和 2,309 名对照者（1,429 名男性，880 名女性）。没有观察到风险与雪茄、烟斗或无烟烟草的使用之间存在关联。吸烟与吸烟存在统计学显着关联，当前吸烟者的风险增加 40% [相对风险 (RR)= 1.4，95% 置信区间 (CI) 1.2-1.7]。风险随着强度（吸烟数量）和持续时间（吸烟年数）的增加而增加。在当前吸烟者中，包年的 RR 从 < 15.9 包年的 1.1 (95% CI 0.8-1.5) 上升到 > 42 包年的 2.0 (95% CI 1.6-2.7)（趋势 p < 0.001）。与当前吸烟者相比，长期戒烟者（> 15 年）的风险降低了约 15-25%。那些较晚开始吸烟（> 24 岁）的人的风险大约是那些年轻时（小于或等于 12 岁）开始吸烟的人的三分之二。总体而言，该汇总分析的结果证实吸烟是 RCC 病因的一个致病因素。 (C) 1995 Wiley-Liss, Inc.(*)
The relationship between renal-cell cancer (RCC) and tobacco use was investigated in an international, multicenter, population-based case-control study. Coordinated studies were conducted in Australia, Denmark, Germany, Sweden and the United States using a shared protocol and questionnaire. A total of 1,732 cases (1,050 men, 682 women) and 2,309 controls (1,429 men, 880 women) were interviewed for the study. No association was observed between risk and use of cigars, pipes or smokeless tobacco. A statistically significant association was observed for cigarette smoking, with current smokers having a 40% increase in risk [relative risk (RR)= 1.4, 95% confidence interval (CI) 1.2-1.7]. Risk increased with intensity (number of cigarettes) and duration (years smoked). Among current smokers the RR for pack-years rose from 1.1 (95% CI 0.8-1.5) for < 15.9 pack years to 2.0 (95% CI 1.6-2.7) for > 42 pack years (p for trend < 0.001). Long-term quitters (> 15 years) experienced a reduction in risk of about 15-25% relative to current smokers. Those who started smoking late (> 24 years of age) had about two-thirds the risk of those who started young (less than or equal to 12 years of age). Overall, the findings of this pooled analysis confirm that cigarette smoking is a causal factor in the etiology of RCC. (C) 1995 Wiley-Liss, Inc.(*)