ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS
ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS
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DOI：
10.1126/science.8018146
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发表时间：
1993-12-17
期刊：
影响因子：
56.9
通讯作者：
NORMARK, S
中科院分区：
文献类型：
--
作者：
BOREN, T;FALK, P;NORMARK, S
幽门螺杆菌与人类胃炎、胃溃疡和腺癌的发生有关。刘易斯（B）（Le（B））血型抗原介导H. pylori附着于人胃粘膜。呈递Le（B）抗原的可溶性糖蛋白或Le（B）抗原的抗体抑制细菌结合。缺乏Le（B）表达的胃组织不结合H.幽门。细菌不与末端被GalNAcalpha 1 -3残基（血型A决定簇）取代的Le（B）抗原结合，表明H.与O型血个体相比，A型和B型血个体的幽门螺杆菌受体可能减少。
Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Le(b) antigen or antibodies to the Le(b) antigen inhibited bacterial binding. Gastric tissue lacking Le(b) expression did not bind H. pylori. Bacteria did not bind to Le(b) antigen substituted with a terminal GalNAcalpha1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.