Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
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DOI：
10.1017/s003329170999239x
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发表时间：
2011-02-01
影响因子：
6.9
通讯作者：
Bramon, E.
中科院分区：
文献类型：
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作者：
Shaikh, M.;Hall, M. -H.;Bramon, E.
背景听觉P50感觉门控缺陷与精神分裂症的遗传风险相关，并构成了该疾病的一个合理的内表型。儿茶酚-O-甲基转移酶（COMT）、脑源性神经营养因子（BDNF）和神经调节蛋白1（NRG 1）基因在神经发育和认知中的作用得到了充分的支持，为它们对P50内表型的影响提供了强有力的理论依据。采用线性回归分析方法，对NRG 1、COMT瓦尔（158）Met和BDNF瓦尔（66）Met基因多态性与P50内表型的关系进行了研究。尽管P50缺陷存在于患者及其未受影响的亲属中，但没有证据表明NRG 1、COMT瓦尔（158）Met或BDNF瓦尔（66）Met基因型与P50内表型之间存在关联。来自我们的大型研究的证据表明，P50指数与NRG 1、COMT瓦尔（158）Met或BDNF瓦尔（66）Met基因型之间的任何此类关联（如果存在）必须非常微妙。
Background. Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.Method. The possible role of NRG1, COMT Val(158)Met and BDNF Val(66)Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.Results. Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val(158)Met or BDNF Val(66)Met genotypes and the P50 endophenotype.Conclusions. The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val(158)Met or BDNF Val(66)Met genotypes, if present, must be very subtle.