Fat-soluble vitamins and atopic disease: what is the evidence?
Fat-soluble vitamins and atopic disease: what is the evidence?
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DOI：
10.1017/s002966511100334x
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发表时间：
2012-02
影响因子：
7
通讯作者：
Litonjua, Augusto A.
中科院分区：
文献类型：
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作者：
Litonjua, Augusto A.
哮喘和其他特应性疾病的患病率在世界范围内持续增加。对流行病学模式的研究表明，这种上升主要发生在西方工业化国家和向这种生活方式过渡的国家。虽然多年来人类发生了许多变化，但据推测，导致哮喘和特应性疾病增加的一些相关变化是从传统饮食向更西式饮食的变化，包括水果和蔬菜摄入量的减少（抗氧化维生素和类胡萝卜素的来源）导致维生素E和A的摄入量减少，和减少阳光照射（例如，更多的时间花在室内和大量使用防晒霜），导致维生素D的循环水平下降。本综述将研究脂溶性维生素（维生素A，D和K）对哮喘和过敏的发展和严重程度的影响的证据。虽然观察性研究表明，这些维生素可能在哮喘和过敏症中发挥有益作用，但缺乏大型，精心设计的临床试验。在脂溶性维生素中，维生素D作为一级和二级预防疾病的药剂具有很大的希望。正在进行的临床试验将有助于确定观察性研究的结果是否可以应用于临床环境。
The prevalence of asthma and other atopic disorders continues to increase worldwide. Examination of the epidemiologic patterns has revealed that this rise has occurred primarily in western, industrialised countries and countries transitioning to this lifestyle. While many changes have occurred in human populations over the years, it has been hypothesised that some of the relevant changes that have led to the rise in asthma and atopic disorders have been the changes from a traditional diet to a more western diet consisting of decreased intake of fruits and vegetables (sources of antioxidant vitamins and carotenoids) leading to decreased intakes of vitamins E and A, and a decrease in sun exposure (e.g. greater time spent indoors and heavy use of sunscreen) leading to decreased circulating levels of vitamin D. This review will examine the evidence for an effect of fat-soluble vitamins (vitamins A, D and K) on the development and severity of asthma and allergies. While observational studies suggest that these vitamins may play a salutary role in asthma and allergies, large, well-designed clinical trials are lacking. Of the fat-soluble vitamins, vitamin D holds great promise as an agent for primary and secondary prevention of disease. Ongoing clinical trials will help determine whether results of observational studies can be applied to the clinical setting.