Some effects of proctolin on the cardiac ganglion of the Maine Lobster, Homarus americanus (Milne Edwards).
Some effects of proctolin on the cardiac ganglion of the Maine Lobster, Homarus americanus (Milne Edwards).
复制标题
Proctolin 对缅因龙虾、美洲白鹤 (Milne Edwards) 心脏神经节的一些影响。
DOI：
10.1002/neu.480120611
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Sullivan,RE
中科院分区：
文献类型：
--
作者：
Miller,MW;Sullivan,RE
神经肽proctolin对离体龙虾心神经节有兴奋作用。选择性应用于前细胞体区域，可使大前细胞产生剂量依赖性（10−8-10− 5 M）去极化延长，以及爆发频率和/或持续时间显著增加。在已被河豚毒素沉默的神经节中，将proctolin应用于前细胞引起持久的去极化反应，伴随着表观膜输入电阻增加10-30%。更高的proctolin浓度产生高频驱动电位序列。有人提出，proctolinlike肽可能在龙虾心神经节中起神经体液作用，并且前运动神经元在其存在下表现出内源性节律性。
The neuropeptide proctolin has excitatory effects on the isolated lobster cardiac ganglion. Selective application to the anterior cell body region produces a dose‐dependent (10−8–10−5M) prolonged depolarization of large anterior cells as well as marked increases in burst frequency and/or duration. In ganglia which have been silenced with tetrodotoxin, proctolin application to anterior cells elicits long‐lasting depolarizing responses which are accompained by a 10–30% increase of the apparent membrane input resistance. Higher proctolin concentrations produce high‐frequency trains of driver potentials. It is proposed that a proctolinlike peptide may serve a neurohumoral role in the lobster cardiac ganglion and that the anterior motor neurons exhibit endogenous rhythmicity in its presence.