A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
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DOI：
10.3945/ajcn.110.002758
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发表时间：
2011-04-01
影响因子：
7.1
通讯作者：
Clarke, Kieran
中科院分区：
文献类型：
--
作者：
Holloway, Cameron J.;Cochlin, Lowri E.;Clarke, Kieran
背景：高脂肪、低碳水化合物饮食被广泛用于减肥，但它们也可能通过增加循环游离脂肪酸浓度产生有害影响。目的：研究通过高脂肪、低碳水化合物饮食提高血浆游离脂肪酸是否会导致健康受试者心脏和大脑的改变。设计：年龄在22 +/- 1岁（平均+/- SE）的男性（n = 16）被随机分配到5天的高脂肪、低碳水化合物饮食，其中75.1%的热量摄入来自脂肪消耗，或等热量标准饮食，其中23% +/- 1%的热量摄入来自脂肪。在交叉设计中，受试者在2周的洗脱期后进行替代饮食，并在饮食期后比较结果。心脏31p磁共振（MR）波谱和磁共振成像、超声心动图和计算机认知测试分别评估心脏磷酸肌酸(PCr)/ATP、心功能和认知功能。结果：与标准饮食相比，高脂低碳水化合物饮食组血浆游离脂肪酸升高44% (P < 0.05)，心脏PCr/ATP降低9% (P < 0.01)，心功能无变化。认知测试显示，高脂低碳水化合物饮食后，注意力（P < 0.01）、速度（P < 0.001）和情绪（P < 0.01）受损。结论：血浆游离脂肪酸升高，心肌PCr/ATP降低，认知能力下降，提示健康人群高脂饮食对心脏和大脑有害。中华临床医学杂志，2011;33(3):748- 755。
Background: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations.Objective: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects.Design: Men (n = 16) aged 22 +/- 1 y (mean +/- SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 6 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 +/- 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. Cardiac 31 P magnetic resonance (MR) spectroscopy and MR imaging, echo-cardiography, and computerized cognitive tests were used to assess cardiac phosphocreatine (PCr)/ATP, cardiac function, and cognitive function, respectively.Results: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet.Conclusion: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects. Am J Clin Nutr 2011;93:748-55.