Literature survey on epidemiology and pathology of gangliocytic paraganglioma.
Literature survey on epidemiology and pathology of gangliocytic paraganglioma.
复制标题
DOI：
10.1186/1471-2407-11-187
复制
发表时间：
2011-05-20
期刊：
影响因子：
3.8
通讯作者：
Hiruta N
中科院分区：
文献类型：
--
作者：
Okubo Y;Wakayama M;Nemoto T;Kitahara K;Nakayama H;Shibuya K;Yokose T;Yamada M;Shimodaira K;Sasai D;Ishiwatari T;Tsuchiya M;Hiruta N
虽然神经节细胞性副神经节瘤（GP）通常被认为是一种神经内分泌肿瘤，但其起源仍不清楚。因此，我们的目的是通过仔细分析和提取所选出版物中呈现的疾病的共同特征来调查这种疾病的细节。我们于2010年8月使用PubMed和IgakuChuoZasshi数据库检索了英文和日文GP病例。然后，我们从选定的出版物中提取和采样原始数据，并进行适当的统计分析。此外，我们评估了激素受体的表达的基础上，我们以前报道的情况。从数据库中检索到192例GP患者。患者年龄范围为15岁至84岁（平均年龄：52.3岁）。性别比为114：76（男：女，2例未报告）。肿瘤最大直径5.5 ~ 100 mm，平均25.0 mm。十二指肠（90.1%，173/192）是最常见的病变部位。在173例十二指肠GP患者中，消化道出血（45.1%，78/173）是最常见的症状，其次是腹痛（42.8%，74/173）和贫血（14.5%，25/173）。淋巴结转移率为6.9%（12/173）。我们的统计学分析表明，在粘膜下层和粘膜下层以外的GP之间存在显著的性别差异。此外，我们的免疫组织化学评价表明，上皮样细胞和胰岛细胞显示阳性反应的孕激素受体。我们的文献调查显示，GP超过粘膜下层的病例比预期的要多得多。同时，我们的统计分析和免疫组化评价支持以下两个假设。第一，孕激素暴露可能会影响GP的垂直生长。第二，GP的来源可能是胰岛细胞。然而，我们强烈怀疑我们的数据受到发表偏倚的影响，为了证实这些假设，需要进一步的调查。
Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing and extracting common features of the disease as presented in selected publications. We searched for English and Japanese cases of GP using the PubMed and IgakuChuoZasshi databases on August 2010. We then extracted and sampled raw data from the selected publications and performed appropriate statistical analyses. Additionally, we evaluated the expression of hormone receptors based on our previously reported case. 192 patients with GP were retrieved from the databases. Patient ages ranged from 15 y to 84 y (mean: 52.3 y). The gender ratio was 114:76 (male to female, 2 not reported). Maximum diameter of the tumors ranged from 5.5 mm to 100 mm (mean: 25.0 mm). The duodenum (90.1%, 173/192) was found to be the most common site of the disease. In 173 patients with duodenal GP, gastrointestinal bleeding (45.1%, 78/173) was found to be the most common symptom of the disease, followed by abdominal pain (42.8%, 74/173), and anemia (14.5%, 25/173). Rate of lymph node metastasis was 6.9% (12/173). Our statistical analysis indicated that significant differences were found for gender between GP within the submucosal layer and exceeding the submucosal layer. Furthermore, our immunohistochemical evaluation showed that both epithelioid and pancreatic islet cells showed positive reactivity for progesterone receptors. Our literature survey revealed that there were many more cases of GP exceeding the submucosal layer than were expected. Meanwhile, our statistical analyses and immunohistochemical evaluation supported the following two hypotheses. First, vertical growth of GP might be affected by progesterone exposure. Second, the origin of GP might be pancreatic islet cells. However, it is strongly suspected that our data have been affected by publication bias and to confirm these hypotheses, further investigation is required.