Molecular motors and synaptic assembly.
Molecular motors and synaptic assembly.
复制标题
DOI：
10.1177/1073858408329511
复制
发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Sheng ZH
中科院分区：
文献类型：
--
作者：
Cai Q;Sheng ZH
正确的突触功能需要突触成分和结构的运输、组装和调节的无缝集成。由于突触通常远离神经元细胞体，因此新合成的突触蛋白、突触小泡的前体、活性区室、通道和受体以及线粒体必须沿着漫长的神经元过程运输以参与突触发生。神经元运输由运动蛋白介导，运动蛋白通过适配器（或受体）与其货物相关联，并沿着神经元过程内的细胞骨架网络移动。因此，膜蛋白货物的身份和运动货物相互作用的特异性对于在发育中的神经元中正确靶向货物和正确组装突触以及响应神经元活动重塑成熟神经元的突触至关重要。在本文中，作者回顾了表征基于微管和肌动蛋白的运动蛋白的最新进展，这些运动蛋白参与传递突触成分，并讨论了运动-受体-货物复合物形成的潜在机制，该复合物有助于突触发生和活动诱导的突触可塑性。
Proper synaptic function requires the seamless integration of the transport, assembly, and regulation of synaptic components and structures. Inasmuch as the synapse is often distant from the neuronal cell body, newly synthesized synaptic proteins, the precursors of synaptic vesicles, active zone compartments, channels and receptors, and mitochondria, must be transported along lengthy neuronal processes to participate in synaptogenesis. Neuronal transport is mediated by motor proteins that associate with their cargoes via adaptors (or receptors) and that travel along the cytoskeleton network within the neuronal processes. Thus, the identity of membranous protein cargoes and the specificity of motor-cargo interactions are critical for correctly targeting cargoes and properly assembling synapses in developing neurons and in remodeling synapses of mature neurons in response to neuronal activity. In this article, the authors review recent progress in characterizing microtubule- and actin-based motor proteins that are involved in delivering synaptic components and discuss potential mechanisms underlying the formation of motor- receptor-cargo complexes that contribute to synaptogenesis and activity-induced synaptic plasticity.