Sex differences in sensorimotor gating of the human startle reflex: all smoke?
Sex differences in sensorimotor gating of the human startle reflex: all smoke?
复制标题
人类惊吓反射感觉运动门控的性别差异：都是烟雾？
DOI：
10.1007/s002130051111
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发表时间：
1999
影响因子：
3.4
通讯作者：
Braff,DL
中科院分区：
文献类型：
--
作者：
Swerdlow,NR;Geyer,MA;Hartman,PL;Sprock,J;Auerbach,PP;Cadenhead,K;Perry,W;Braff,DL
基本原理：最近的一份报告描述了尼古丁使用和戒断对声惊吓（PPI）前脉冲抑制的影响存在性别差异，但非吸烟者的PPI无性别差异。目的：确定先前报道的男性>女性声PPI是否反映了吸烟对PPI影响的性别差异，而不是PPI调节的简单性别差异。一项回顾性分析的>600仔细筛选的正常测试在过去12 years covered.Results：男性>女性的声学PPI检测分析，包括：1）所有科目;或2）自称non-smoking.Conclusions：PPI的性别差异不能解释吸烟史，因为他们存在于一个大样本的非吸烟正常对照。
Rationale:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers.Objective:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of >600 carefully screened normals tested over the past 12 years was completed.Results:Male>female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers.Conclusions:Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.