Cellular functions of Rab GTPases at a glance
Cellular functions of Rab GTPases at a glance
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DOI：
10.1242/jcs.166074
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发表时间：
2015-09-01
影响因子：
4
通讯作者：
Stenmark, Harald
中科院分区：
文献类型：
--
作者：
Zhen, Yan;Stenmark, Harald
Rab GTP酶通过以GTP依赖性方式将特异性效应蛋白募集到限制性膜来控制细胞内膜运输。在这篇细胞科学一瞥和随附的海报中，我们强调了控制其膜缔合和激活状态的蛋白质对Rab GTP酶的调节，并概述了Rab GTP酶及其效应物调节的细胞过程，包括蛋白质分选，囊泡运动和囊泡束缚。我们还讨论了Rab GTP酶的生理重要性，并提供了由其功能障碍引起的疾病的例子。
Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the accompanying poster, we highlight the regulation of Rab GTPases by proteins that control their membrane association and activation state, and provide an overview of the cellular processes that are regulated by Rab GTPases and their effectors, including protein sorting, vesicle motility and vesicle tethering. We also discuss the physiological importance of Rab GTPases and provide examples of diseases caused by their dysfunctions.