Relation between infantile colic and asthma/atopy:: A prospective study in an unselected population
Relation between infantile colic and asthma/atopy:: A prospective study in an unselected population
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DOI：
10.1542/peds.108.4.878
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发表时间：
2001-10-01
期刊：
影响因子：
8
通讯作者：
Martinez, FD
中科院分区：
文献类型：
--
作者：
Castro-Rodríguez, JA;Stern, DA;Martinez, FD
Objective.评估有婴儿绞痛病史的儿童随后发生哮喘和/或特应性过敏的风险是否会增加。方法。我们使用的数据是在一项大型的前瞻性研究中从一个大样本人群中收集的。婴儿绞痛和同时喂养方法，确定从2个月的良好的婴儿访问表完成的医生为983名儿童出生时登记。特应性标志物（总血清免疫球蛋白E和过敏性皮肤点刺试验）、过敏性鼻炎、哮喘、喘息和峰值血流变异性是研究婴儿期至11岁不同年龄段的主要结果指标。90例（9.2%）患儿有婴儿绞痛。无论是母乳喂养还是配方奶粉喂养的儿童，绞痛的患病率相似。在任何年龄，婴儿绞痛与特应性、哮喘、过敏性鼻炎、喘息或峰值血流变异性的标志物之间均无关联。我们的数据不能支持婴儿绞痛增加随后过敏性疾病或特应性的风险这一假设。
Objective. To assess whether children with history of infantile colic may be at increased risk of subsequently developing asthma and/or atopy.Methods. We used data collected in a large, prospective study from an unselected population. Infantile colic and concurrent feeding method were determined from the 2-month well-infant visit form completed by the physician for 983 children who were enrolled at birth. Markers of atopy (total serum immunoglobulin E and allergy skin prick test), allergic rhinitis, asthma, wheezing, and peak flow variability were the main outcome measures studied at different ages between infancy and 11 years.Results. Ninety (9.2%) children had infantile colic. Prevalence of colic was similar among children fed either breast milk or formula. There was no association between infantile colic and markers of atopy, asthma, allergic rhinitis, wheezing, or peak flow variability at any age.Conclusion. Our data cannot support the hypothesis that infantile colic provides increased risk for subsequent allergic disease or atopy.