The repeated sit-to-stand maneuver is a superior method for cardiac baroreflex assessment: a comparison with the modified Oxford method and Valsalva maneuver
The repeated sit-to-stand maneuver is a superior method for cardiac baroreflex assessment: a comparison with the modified Oxford method and Valsalva maneuver
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DOI：
10.1152/ajpregu.00376.2014
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发表时间：
2014-12-01
影响因子：
2.8
通讯作者：
Peebles, K. C.
中科院分区：
文献类型：
--
作者：
Horsman, H. M.;Tzeng, Y. C.;Peebles, K. C.
压力反射评估在临床和研究环境中具有诊断和预后效用，并且需要可靠、简单、非侵入性的评估方法。重复的坐立法以期望的频率诱导血压（BP）的振荡变化，并且适合于评估动态压力反射敏感性（BRS）。然而，很少有人知道这种方法的可靠性和它的能力，辨别压力反射的基本属性。在这项研究中，我们试图：1）评估的可靠性，坐到站的方法评估BRS和比较其性能与两个既定的方法（牛津方法和Valsalva动作），和2）检查是否坐到站的方法的频率影响滞后。16名健康参与者接受了每种方法的三次试验。对于在0.1和0.05 Hz下进行的坐立法，将BRS定量为综合反应（BRSINT）以及对血压下降和上升的反应（分别为BRSDOWN和BRSINT）。重测信度采用组内相关系数（ICC）进行评估。无论频率如何，在坐立法期间BRSINT的ICC>= 0.88。在牛津方法中，苯丙氨酸（PEGAIN）引起的血压升高的ICC为0.78，
Baroreflex assessment has diagnostic and prognostic utility in the clinical and research environments, and there is a need for a reliable, simple, noninvasive method of assessment. The repeated sit-to-stand method induces oscillatory changes in blood pressure (BP) at a desired frequency and is suitable for assessing dynamic baroreflex sensitivity (BRS). However, little is known about the reliability of this method and its ability to discern fundamental properties of the baroreflex. In this study we sought to: 1) evaluate the reliability of the sit-to-stand method for assessing BRS and compare its performance against two established methods (Oxford method and Valsalva maneuver), and 2) examine whether the frequency of the sit-to-stand method influences hysteresis. Sixteen healthy participants underwent three trials of each method. For the sit-to-stand method, which was performed at 0.1 and 0.05 Hz, BRS was quantified as an integrated response (BRSINT) and in response to falling and rising BP (BRSDOWN and BRSUP, respectively). Test retest reliability was assessed using the intraclass correlation coefficient (ICC). Irrespective of frequency, the ICC for BRSINT during the sit-to-stand method was >= 0.88. The ICC for a rising BP evoked by phenylephrine (PEGAIN) in the Oxford method was 0.78 and