Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults
Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults
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DOI：
10.3389/fnagi.2018.00313
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发表时间：
2018-10-09
影响因子：
4.8
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
--
作者：
Beydoun, May A.;Dore, Gregory A.;Zonderman, Alan B.
目的/背景：全身性炎症会随着时间的推移影响认知能力。目前的研究检查了非裔美国人和白人城市成年人的全身炎症和认知能力之间的关联，按性别、年龄组和种族分层。患者/方法：在1，555 - 1，719名白色和非裔美国人城市成年人中[年龄（基础）：30- 64岁，2004-2013年，平均+/- SD随访时间（y）：4.64 +/-0.93 y]，进行线性混合效应回归模型，以测试炎症标志物[C-反应蛋白、红细胞沉降率（ESR）、白蛋白、铁和炎症综合评分（ICS）]与纵向认知表现的相关性。在关键发现中，CRP与年轻女性的基线精神状态较差有关（50 y，gamma（01）= -0.024 +/- 0.007，p < 0.004）和非裔美国人（gamma（01）= -0.029 +/- 0.008，p < 0.001）。ESR与老年男性的非文字记忆力下降更快有关（> 50岁，γ（11）= -0.008 +/- 0.003，P = 0.009）;在注意力测试中表现较差（gamma（01）= -0.010 +/- 0.003，P = 0.003）和非裔美国人中（gamma（01）= -0.013 +/- 0.004，P = 0.002）;老年妇女的语言流畅性（> 50岁，γ（01）= -0.037 +/- 0.013，P = 0.004）和执行功能：总体（γ（01）= +0.62 +/- 0.21，P = 0.004），老年男性（> 50岁，γ（01）= +1.69 +/- 0.53，P = 0.001）和非洲裔美国人（γ（01）= +0.84 +/- 0.28，P = 0.002）。白蛋白与老年男性注意力下降速度较慢有关（> 50岁，gamma（11）= +0.329 +/- 0.103，P = 0.009），总体执行功能随时间改善（gamma（11）= -6.00 +/- 2.26，P = 0.008），非裔美国人的基线心理速度更好（gamma（01）= +0.56 +/- 0.19，P = 0.003）。最后，ICS预测老年男性的视觉记忆/视觉建构能力下降更快（> 50岁，γ（11）= +0.17 +/- 0.06，p = 0.003）。结论：总之，检测到全身炎症和纵向认知能力之间存在强相关性，主要是在老年人（> 50岁）和非洲裔美国人中。针对炎症的随机试验是必要的。
Objectives/Background: Systemic inflammation can affect cognitive performance over time. The current study examined associations between systemic inflammation and cognitive performance among African Americans and Whites urban adults, stratifying by sex, and age group and by race.Patients/Methods: Among 1,555-1,719 White and African-American urban adults [Age(base): 30-64y, 2004-2013, mean +/- SD follow-up time(y): 4.64 +/- 0.93y], conducted linear mixed-effects regression models were conducted to test associations of inflammatory markers [C-reactive protein, Erythrocyte Sedimentation Rate (ESR), albumin, iron, and an inflammation composite score (ICS)] with longitudinal cognitive performance.Results: Among key findings, CRP was linked to poorer baseline mental status among younger women (50y, gamma(01) = -0.024 +/- 0.007, p < 0.004) and African-Americans (gamma(01) = -0.029 +/- 0.008, p < 0.001). ESR was related to faster decline on verbal memory among older men (>50y, gamma(11) = -0.008 +/- 0.003, P = 0.009); with poorer performance on attention tests overall (gamma(01) = -0.010 +/- 0.003, P = 0.003) and among African-Americans (gamma(01) = -0.013 +/- 0.004, P = 0.002); on verbal fluency among older women (>50y, gamma(01) = -0.037 +/- 0.013, P = 0.004) and on executive function: overall (gamma(01) = +0.62 +/- 0.21, P = 0.004), older men (>50y, gamma(01) = +1.69 +/- 0.53, P = 0.001) and African-Americans (gamma(01) = +0.84 +/- 0.28, P = 0.002). Albumin was linked to slower attention decline among older men (>50y, gamma(11) = +0.329 +/- 0.103, P = 0.009), over-time improvement in executive function overall (gamma(11) = -6.00 +/- 2.26, P = 0.008), and better baseline psychomotor speed among African-Americans (gamma(01) = +0.56 +/- 0.19, P = 0.003). Finally, ICS predicted faster decline on visual memory/visuo-constructive abilities among older men (>50y, gamma(11) = +0.17 +/- 0.06, p = 0.003).Conclusion: In sum, strong associations between systemic inflammation and longitudinal cognitive performance were detected, largely among older individuals (>50y) and African-Americans. Randomized trials targeting inflammation are warranted.