Core-shell-shell nanorods for controlled release of silver that can serve as a nanoheater for photothermal treatment on bacteria
Core-shell-shell nanorods for controlled release of silver that can serve as a nanoheater for photothermal treatment on bacteria
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用于控制银释放的核-壳-壳纳米棒，可用作细菌光热处理的纳米加热器
DOI：
10.1016/j.actbio.2014.09.005
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发表时间：
2015-01-01
影响因子：
9.7
通讯作者：
Wang, Jian-Hua
中科院分区：
文献类型：
--
作者：
Hu, Bo;Wang, Ning;Wang, Jian-Hua
一种新型杀菌材料，包括棒状核-壳-壳Au-Ag-Au纳米棒，被构造为近红外（NIR）区域的纳米加热器。外部Au壳在激光照射下熔化并导致内部Ag壳暴露，从而促进抗菌Ag壳/层或Ag+的受控释放。这导致Au-Ag-Au纳米棒具有良好的杀菌能力，因为它结合了外部Au壳的物理光热消融杀菌和内部Ag壳或Ag+对周围细菌的抗菌效果的特征。以大肠杆菌O 157：H7为模型菌，研究了Au-Ag-Au纳米棒的杀菌能力。在低功率NIR激光照射（785 nm，50 mW cm（-2））下，Au-Ag-Au纳米加热器相对于Au-Ag纳米棒（39 ℃）表现出更高的光热转换效率（溶液温度为44 ℃）。同时，观察到相对于Au-Ag纳米棒的大大改善的稳定性，即，连续16天的监测揭示了Au-Ag-Au纳米棒的紫外-可见光谱几乎没有变化，而对于Au-Ag纳米棒记录了吸收沿着的显著下降以及局部表面等离子体共振的92 nm红移。这为Au-Ag-Au纳米棒带来了增加的杀菌效率和长期稳定性。在10 μ g·ml ~（-1）剂量下，对大肠杆菌的杀灭率达100%。coliO 157：H7细胞。Au-Ag-Au纳米棒的使用避免了广谱抗生素的滥用，并通过控制释放和使用低功率激光照射来减轻银的毒性，从而减少了对组织的损伤。这些特性使得这种核-壳-壳结构的纳米棒成为生物医学应用中的一种良好的纳米加热器。(C)2014 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
A novel bactericidal material comprising rod-shaped core-shell-shell Au-Ag-Au nanorods is constructed as a nanoheater in the near-infrared (NIR) region. The outer Au shell melts under laser irradiation and results in exposure of the inner Ag shell, facilitating the controlled release of the antibacterial Ag shell/layer or Ag+. This results in the Au-Ag-Au nanorods having a favorable bactericidal ability as it combines the features of physical photothermal ablation sterilization of the outer Au shell and the antibacterial effect of the inner Ag shell or Ag+ to the surrounding bacteria. The sterilizing ability of Au-Ag-Au nanorods is investigated with Escherichia coli O157:H7 as a model bacterial strain. Under low-power NIR laser irradiation (785 nm, 50 mW cm(-2)), the Au-Ag-Au nanoheater exhibits a higher photothermal conversion efficiency (with a solution temperature of 44 degrees C) with respect to that for the Au-Ag nanorods (39 degrees C). Meanwhile, a much improved stability with respect to Au-Ag nanorods is observed, i.e., 16 successive days of monitoring reveal virtually no change in the ultraviolet-visible spectrum of Au-Ag-Au nanorods, while a significant drop in absorption along with a 92 nm red shift of Localized Surface Plasmon Resonance is recorded for the Au-Ag nanorods. This brings an increasing bactericidal efficiency and long-term stability for the Au-Ag-Au nanorods. At a dosage of 10 mu g ml(-1), a killing rate of 100% is reached for the E. coli O157:H7 cells under 20 min of irradiation. The use of Au-Ag-Au nanorods avoids the abuse of broad-spectrum antibiotics and reduces the damage of tissues by alleviating the toxicity of silver under controlled release and by the use of low-power laser irradiation. These features could make the bimetallic core-shell-shell nanorods a favorable nanoheater for in vivo biomedical applications. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.