Premature centromere division in three unrelated families.
Premature centromere division in three unrelated families.
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三个不相关家族的过早着丝粒分裂。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
G. Gündüz
中科院分区：
文献类型：
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作者：
I. Keser;G. Lüleci;G. Gündüz
我们描述了三个不相关的家庭与过早的着丝粒分裂（PCD）在所有的染色体细胞的频率增加。在这些家系中有8个表型正常的PCD个体。家族性细胞程序死亡现象与所描述的X染色体和罗伯茨综合征患者细胞的细胞程序死亡不同。在这项研究中，我们讨论了我们的研究结果，在不同的介质和时间，并与/不秋水仙胺的情况下，自然流产和父亲的孩子谁有染色体异常。在我们的家庭中，这种异常是以一种与常染色体显性遗传相容的方式传播的。
We describe three unrelated families with an increased frequency of cells with premature centromere division (PCD) in all of the chromosomes. There were eight phenotypically normal individuals with PCD in these families. Familial PCD phenomenon is different from the described PCD of X chromosome and of the cells of patients with Roberts syndrome. In this study, we discussed our findings in different medium and time and with/without colcemid in cases referred with spontaneous abortions and in the father of a child who had chromosomal abnormality. In our families, this anomaly was transmitted in a way compatible with autosomal dominant inheritance.