44gSC production using a water target on a 13 MeV cyclotron
44gSC production using a water target on a 13 MeV cyclotron
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DOI：
10.1016/j.nucmedbio.2013.12.016
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发表时间：
2014-05-01
影响因子：
3.1
通讯作者：
Schaffer, Paul
中科院分区：
文献类型：
--
作者：
Hoehr, Cornelia;Oehlke, Elisabeth;Schaffer, Paul
简介：要获得有前途的放射性金属作为新型分子成像剂的同位素，需要它们可以常规获得且价格低廉。必须靠近配备有固体目标硬件的回旋加速器中心，或靠近目标金属的同位素发生器，这两者都会给不太常见的同位素的开发带来重大障碍。在这里，我们描述了Sc-44（t（1/2）= 3.97 h，E-avg，beta（+）= 1.47 MeV，分支比= 94.27％）在解决方案目标和自动加载系统中的生产，该系统允许不同放射性金属同位素之间的快速周转，因此大大提高了示踪剂开发的可用性。将实验产率与理论计算结果进行比较。方法：使用标准液体靶在 13 MeV 质子束回旋加速器上照射含有高浓度 (1.44-1.55 g/mL) 天然丰度四水合硝酸钙 (Ca(NO3)(2) 中心点 4 H2O）的溶液。 Sc-44g 通过 Ca-44(p,n)Sc-44g 反应产生。结果：Sc-44g 首次在溶液靶中产生，产量足以用于早期放射化学研究。使用 7.6 +/- 03 mu A 质子束持续 60.0 +/- 0.2 分钟（运行次数 n = 3）可实现高达 4.6 +/- 0.3 MBq/mu A 的饱和产率。实验数据和计算结果非常一致 通过固相萃取从目标混合物中分离出钪，效率为 88 +/- 6% (n = 5)，并成功用于放射性标记实验。在液体靶中生产 Sc-44 的演示极大地提高了示踪剂开发的可用性。 (C) 2014 Elsevier Inc. 保留所有权利。
Introduction: Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of Sc-44 (t(1/2) = 3.97 h, E-avg,beta(+) = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.Methods: Solutions containing a high concentration (1.44-1.55 g/mL) of natural-abundance calcium nitrate tetrahydrate (Ca(NO3)(2) center dot 4 H2O) were irradiated on a 13 MeV proton-beam cyclotron using a standard liquid target. Sc-44g was produced via the Ca-44(p,n)Sc-44g reaction.Results: Sc-44g was produced for the first time in a solution target with yields sufficient for early radiochemical studies. Saturation yields of up to 4.6 +/- 0.3 MBq/mu A were achieved using 7.6 +/- 03 mu A proton beams for 60.0 +/- 0.2 minutes (number of runs n = 3). Experimental data and calculation results are in fair agreement Scandium was isolated from the target mixture via solid-phase extraction with 88 +/- 6% (n = 5) efficiency and successfully used for radiolabelling experiments. The demonstration of the production of Sc-44 in a liquid target greatly improves its availability for tracer development. (C) 2014 Elsevier Inc. All rights reserved.