A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1
A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1
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DOI：
10.1080/15384101.2015.1104440
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发表时间：
2015-11-17
期刊：
影响因子：
4.3
通讯作者：
Sashchenko, L. P.
中科院分区：
文献类型：
--
作者：
Dukhanina, E. A.;Lukyanova, T. I.;Sashchenko, L. P.
PGRP-S（Tag7）是一种天然免疫蛋白，参与昆虫和哺乳动物的抗微生物防御系统。我们以前已经表明，Tag7特异性地与几种蛋白质相互作用，包括热休克蛋白70和钙结合蛋白S100A4（Mts1），提供了一些新的细胞功能。在这里，我们表明，Tag7-Mts1复合物导致淋巴细胞的趋化性迁移，NK细胞是一个首选的目标。先天性免疫细胞（中性粒细胞和单核细胞）或获得性免疫细胞（CD4（+）和CD8（+）淋巴细胞）可以产生这种复合物，这证实了免疫反应的两个分支之间的密切联系。
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7-Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4(+) and CD8(+) lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.