Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
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DOI：
10.1093/ijnp/pyz059
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发表时间：
2020-01-01
影响因子：
4.8
通讯作者：
Lanzenberger, Rupert
中科院分区：
文献类型：
--
作者：
Gryglewski, Gregor;Seiger, Rene;Lanzenberger, Rupert
背景：难治性抑郁症是精神病学中最令人衰弱的疾病之一。最近的研究表明，磁共振成像测量的白色物质微结构的改变与抗抑郁反应不良有关。因此，在何种程度上电休克治疗，最有效的治疗选择治疗性抑郁症，影响白色物质的微观结构warrantyinvestigation.Methods：共13例患者患有严重的单极治疗性抑郁症进行磁共振成像与扩散张量成像序列之前和之后进行了一系列的右侧单侧电休克治疗。扩散度指标进行了比较体素明智的使用tract为基础的空间统计和重复测量AN0VA.Results：共有12例患者响应电休克治疗和9被归类为缓解。在右半球内囊的后肢观察到轴向扩散率的增加（P-FWE
Background: Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatmentresistant depression, affects white matter microstructure warrants investigation.Methods: A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeated-measures ANOVA.Results: A total 12 patients responded to electroconvulsive therapy and 9 were classified as remitters. An increase in axial diffusivity was observed in the posterior limb of the internal capsule of the right hemisphere (P-FWE