Gender -based functional connectivity differences in brain networks in childhood
Gender -based functional connectivity differences in brain networks in childhood
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DOI：
10.1016/j.cmpb.2020.105444
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发表时间：
2020-08-01
影响因子：
6.1
通讯作者：
Bas, Abdullah
中科院分区：
文献类型：
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作者：
Icer, Semra;Acer, Irem;Bas, Abdullah
背景与目的了解性别差异对大脑的影响，可以为描述整个生命过程中的正常变化提供重要信息，并增加神经和精神疾病的性别特异性方法的可能性。在这项研究中，功能连接（FC），低频波动幅度（ALFF）和分数ALFF（fALFF）分析将使用静息状态功能磁共振成像（rs-fMRI）在7和18岁之间的女性和男性大脑之间进行比较。儿童研究中心的公共共享ADHD 200数据库。从纽约大学数据集中，选择了68名（34名女性，34名男性）年龄范围为7-18岁的健康受试者。女性组（平均年龄：12.3271±3.1380）和男性组（平均年龄：11.8766±2.9697）均为右利手，头部运动幅度较小，智商值相近。通过种子体素分析获得FC，并通过ALFF和fALFF分析检查低频波动对性别的影响。结果在ALFF、fALFF分析中，以及种子区属于多个网络区的情况下，女生FC率均高于男生。我们的研究结果表明，女性的语言功能，视觉功能，如物体检测和识别，工作记忆，执行功能，情节记忆比男性在这个年龄段更发达。此外，作为我们的研究的另一个结果，种子区域是统计学上更强的女性参与者比男性参与者更高的激活集中在左半球。ConclusionsGender差异在大脑网络应考虑到当检查儿童认知和神经精神疾病和结果也应根据性别进行评估。对儿童期性别差异的评估可以增加神经系统疾病的早期和明确诊断和正确治疗的可能性，并可以帮助医生和科学家找到新的诊断工具来发现大脑差异。
Background and objectiveUnderstanding the effect of gender differences on the brain can provide important information to characterize normal changes throughout life and to increase the likelihood of sex-specific approaches for neurological and psychiatric diseases. In this study, Functional Connectivity (FC), Amplitude of Low-Frequency Fluctuations (ALFF) and fractional ALFF (fALFF) analyzes will be compared between female and male brains between the ages of 7 and 18 years using resting state-functional magnetic resonance imaging (rs-fMRI).MethodsThe rs-fMRI data in this study has been provided by The New York University (NYU) Child Study Center of the publicly shared ADHD200 database. From the NYU dataset, 68 (34 females, 34 males) healthy subjects in the age range of 7–18 years were selected. The female group (mean age: 12.3271±3.1380) and male group (mean age: 11.8766±2.9697) consisted of right-handed, small head motion and similar IQ values. FC was obtained by seed voxel analysis and the effect of low-frequency fluctuations on gender was examined by ALFF and fALFF analyses. Two-samplet-test was used to compare female and male groups with the significance thresholds set to FDR-correctedp<0.05.ResultsIn the results of our study, both in the ALFF, fALFF analyses and the seed regions belonging to many network regions, higher FC rates were found in girls than boys. Our results show that the females’ language functions, visual functions such as object detection and recognition, working memory, executive functions, and episodic memory are more developed than males in this age range. In addition, as another result of our study, the seed regions are statistically stronger where the higher activation of female participants than male participants has concentrated in the left hemisphere.ConclusionsGender differences in brain networks should be taken into consideration when examining childhood cognitive and neuropsychiatric disorders and the results should also be evaluated according to gender. Evaluation of gender differences in childhood can increase the likelihood of early and definitive diagnosis and correct treatment for neurological diseases and can help doctors and scientists find new diagnostic tools to discover brain differences.