RELATIONSHIP OF ANALGESIA INDUCED BY CENTRALLY INJECTED CALCITONIN TO THE CNS SEROTONERGIC SYSTEM
RELATIONSHIP OF ANALGESIA INDUCED BY CENTRALLY INJECTED CALCITONIN TO THE CNS SEROTONERGIC SYSTEM
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DOI：
10.1016/0143-4179(86)90053-3
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发表时间：
1986-10-01
期刊：
影响因子：
2.9
通讯作者：
FERRI, S
中科院分区：
文献类型：
--
作者：
GUIDOBONO, F;NETTI, C;FERRI, S
在大鼠中研究了血清素能系统在中央给药鲑鱼降钙素（sCT）的抗伤害效应中的作用。动物分别接受脑室内（i.c.v）或鞘内（i.t） sCT。静脉注射sCT （2.5 μ）。g/大鼠)对CNS血清素（5-羟色胺）衰竭的动物，分别给予25 mg/kg去甲基咪唑胺（DMI） i.p.加100 .mu。5,7二羟色胺（5,7 DHT）灌胃10 d或对氯苯丙氨酸（pCPA）灌胃150 mg/kg、72和24 h，仍显著增加热板潜伏期，与未消耗的动物相当。用美高梅碱阻断5-HT受体时，结果相同。sCT的it管理（2 .mu）。g/大鼠)对经DMI加5,7 DHT治疗后脊髓5- ht减少的动物，延迟但不消除注射t的sCT的抗伤害感受活性，其强度与未减少的动物相同。当单独给药5,7 DHT时，无论是体外注射还是静脉注射，没有保护儿茶酚胺能神经元，使去甲肾上腺素（NA）大大减少，即使NA仅在脊髓中被耗尽，sCT的抗伤害性作用也被完全消除。我们的结论是儿茶酚胺能系统，而不是5 -羟色胺能系统，在中央给药的sCT的抗伤害作用中起着重要作用。
The role of the serotonergic system in the antinociceptive effect of centrally administered salmon calcitonin (sCT) was studied in rats. The animals were given sCT either intracerebroventricularly (i.c.v.) or intrathecally (i.t.). I.c.v. administration of sCT (2,5 .mu.g/rat) to animals depleted in CNS serotonin (5-HT) either by treatment with 25 mg/kg desmethylimipramine (DMI) i.p. plus 100 .mu.g/rat 5,7 dihydroxytryptamine (5,7 DHT) i.c.v., ten days before or by 150 mg/kg p-chlorophenylalanine (pCPA) i.p., 72 and 24 h before, still significantly increased the hot-plate latencies comparable to those of non-depleted animals. The same result was obtained when the 5-HT receptors were blocked with metergoline. The i.t. administration of sCT (2 .mu.g/rat) to animals with spinal cord 5-HT depleted by treatment with DMI plus 5,7 DHT, i.t., delayed but did not abolish the antinociceptive activity of i.t. injected sCT, which was of the same intensity as in non-depleted animals. When 5,7 DHT was administered alone, either i.c.v. or i.t., without protection of the catecholaminergic neurons so that noradrenaline (NA) was greatly reduced, the antinociceptive effect of sCT was completely abolished even when NA had been depleted only in the spinal cord. We conclude that it is the catecholaminergic system, not the serotonergic, that plays a fundamental role in the anti-nociceptive effect of centrally administered sCT.