Cortical hemoglobin-concentration changes under the coil induced by single-pulse TMS in humans: a simultaneous recording with near-infrared spectroscopy
Cortical hemoglobin-concentration changes under the coil induced by single-pulse TMS in humans: a simultaneous recording with near-infrared spectroscopy
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DOI：
10.1007/s00221-005-0149-0
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发表时间：
2006-03-01
影响因子：
2
通讯作者：
Sakai, KL
中科院分区：
文献类型：
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作者：
Mochizuki, H;Ugawa, Y;Sakai, KL
我们使用近红外光谱（NIRS）同步记录技术测量了单脉冲经颅磁刺激（TMS）引起的线圈下皮质血红蛋白浓度的变化。单脉冲TMS在左初级运动皮层的手部区域以主动运动阈值（AMT）的100、120或140%的强度进行传递。在假刺激期间也进行NIRS记录。当受试者轻微收缩右侧第一背侧骨间肌时和放松时（活动和静息条件），进行这四种不同的刺激会话（三种强度的TMS和假刺激）。在TMS为100%AMT的活动条件下，我们观察到氧合血红蛋白（oxy-Hb）的短暂增加，其显著大于假刺激。在120和140%AMT的TMS的静息条件下，我们观察到与假刺激相比，脱氧血红蛋白（deoxyHb）和总血红蛋白（total-Hb）均显著降低。我们认为，氧-Hb浓度的增加，在100%AMT下的活动条件下反映了附加效应TMS的活动基线和脱氧-Hb和总-Hb浓度的减少，在120和140%AMT下的休息条件下是由于减少基线发射的皮质脊髓束神经元引起的持久抑制挑起的更高强度的TMS。
We measured cortical hemoglobin-concentration changes under the coil induced by single-pulse transcranial magnetic stimulation (TMS) using a technique of simultaneous recording with near-infrared spectroscopy (NIRS). Single-pulse TMS was delivered over the hand area of the left primary motor cortex at an intensity of 100, 120, or 140% of the active motor threshold (AMT). NIRS recordings were also made during sham stimulation. These four different stimulation sessions (TMS at three intensities and sham stimulation) were performed both when the subject slightly contracted the right first dorsal interosseous muscle and when relaxed it (active and resting conditions). Under the active condition with TMS at 100% AMT, we observed a transient increase in oxy-hemoglobin (oxy-Hb), which was significantly larger than sham stimulation. Under the resting conditions with TMS at 120 and 140% AMT, we observed significant decreases in both deoxy-hemoglobin (deoxyHb) and total-hemoglobin (total-Hb) as compared to sham stimulation. We suggest that the increase of oxy-Hb concentration at 100% AMT under the active condition reflects an add-on effect by TMS to the active baseline and that decrease of deoxy-Hb and total-Hb concentrations at 120 and 140% AMT under the resting condition are due to reduced baseline firings of the corticospinal tract neurons induced by a lasting inhibition provoked by a higher intensity TMS.