Institution of basal-bolus therapy at diagnosis for children with type 1 diabetes mellitus.
Institution of basal-bolus therapy at diagnosis for children with type 1 diabetes mellitus.
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DOI：
10.1542/peds.2008-3027
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发表时间：
2009-04
期刊：
影响因子：
8
通讯作者：
White PC
中科院分区：
文献类型：
--
作者：
Adhikari S;Adams-Huet B;Wang YC;Marks JF;White PC
We studied whether the institution of basal-bolus therapy immediately after diagnosis improved glycemic control in the first year after diagnosis for children with newly diagnosed type 1 diabetes mellitus. We reviewed the charts of 459 children ≥6 years of age who were diagnosed as having type 1 diabetes between July 1, 2002, and June 30, 2006 (212 treated with basal-bolus therapy and 247 treated with a more-conventional neutral protamine Hagedorn regimen). We abstracted data obtained at diagnosis and at quarterly clinic visits and compared groups by using repeated-measures, mixed-linear model analysis. We also reviewed the records of 198 children with preexisting type 1 diabetes mellitus of >1-year duration who changed from the neutral protamine Hagedorn regimen to a basal-bolus regimen during the review period. Glargine-treated subjects with newly diagnosed diabetes had lower hemoglobin A1c levels at 3, 6, 9, and 12 months after diagnosis than did neutral protamine Hagedorn-treated subjects (average hemoglobin A1c levels of 7.05% with glargine and 7.63% with neutral protamine Hagedorn, estimated across months 3, 6, 9, and 12, according to repeated-measures models adjusted for age at diagnosis and baseline hemoglobin A1c levels; treatment difference: 0.58%). Children with long-standing diabetes had no clinically important changes in their hemoglobin A1c levels in the first year after changing regimens. The institution of basal-bolus therapy with insulin glargine at the time of diagnosis of type 1 diabetes was associated with improved glycemic control, in comparison with more-conventional neutral protamine Hagedorn regimens, during the first year after diagnosis.
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影响因子：
16.2
作者：
Raskin, P;Klaff, L;Mecca, T
通讯作者：
Mecca, T
DOI：
10.1111/j.1651-2227.1982.tb09546.x
发表时间：
1982-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
KNIP, M;SAKKINEN, A;AKERBLOM, HK
通讯作者：
AKERBLOM, HK
影响因子：
7.7
作者：
Herold KC;Gitelman SE;Masharani U;Hagopian W;Bisikirska B;Donaldson D;Rother K;Diamond B;Harlan DM;Bluestone JA
通讯作者：
Bluestone JA
影响因子：
8
作者：
Hassan, Krishnavathana;Rodriguez, Luisa M.;Heptulla, Rubina A.
通讯作者：
Heptulla, Rubina A.
影响因子：
158.5
作者：
Herold, KC;Hagopian, W;Bluestone, JA
通讯作者：
Bluestone, JA