Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound
Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound
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DOI：
10.1007/s00330-015-3698-z
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发表时间：
2015-10-01
影响因子：
5.9
通讯作者：
Chung, Namsik
中科院分区：
文献类型：
--
作者：
Park, Hyung-Bok;Lee, Byoung Kwon;Chung, Namsik
评估不同用户（专家/非专家/自动）自动冠状动脉粥样硬化斑块定量（QCT）的诊断性能。对142例接受冠状动脉ct血管造影（CCTA）和血管内超声（IVUS）检查的患者的150条冠状动脉段进行了分析。最小管腔面积（MLA）、最大管腔面积狭窄百分比（%AS）、平均斑块负担百分比（%PB）和斑块体积由专家、非专家和全自动QCT分析半自动测量，然后与IVUS进行比较。在IVUS和专家QCT分析之间，MLA、%AS、%PB和斑块体积的相关系数(r)分别为0.89 （p < 0.001）、0.84 （p < 0.001）、0.91 （p < 0.001）和0.94 （p < 0.001）。除%AS （p = 0.01）外，各组平均参数差异无统计学意义（p值均为0.05）。与IVUS相比，自动QCT分析显示出与非专家QCT分析相当的性能，分别显示MLA （0.80 vs. 0.82）、%AS （0.82 vs. 0.80）、%PB （0.84 vs. 0.73）和斑块体积（0.84 vs. 0.79）的相关系数(r)。全自动QCT分析与IVUS相比具有临床实用性，与半自动分析相比具有令人信服的性能。冠状动脉CTA可以评估冠状动脉粥样硬化斑块。高危斑块特征和总体斑块负荷可以预测未来的心脏事件。冠状动脉粥样硬化斑块定量目前在实践中是不可行的。定量计算机断层扫描冠状动脉斑块分析软件（QCT）使斑块量化可行。全自动QCT分析性能优异。
To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic).One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS) were analyzed. Minimal lumen area (MLA), maximal lumen area stenosis percentage (%AS), mean plaque burden percentage (%PB), and plaque volume were measured semi-automatically by expert, non-expert, and fully automatic QCT analyses, and then compared to IVUS.Between IVUS and expert QCT analysis, the correlation coefficients (r) for the MLA, %AS, %PB, and plaque volume were excellent: 0.89 (p < 0.001), 0.84 (p < 0.001), 0.91 (p < 0.001), and 0.94 (p < 0.001), respectively. There were no significant differences in the mean parameters (all p values > 0.05) except %AS (p = 0.01). The automatic QCT analysis showed comparable performance to non-expert QCT analysis, showing correlation coefficients (r) of the MLA (0.80 vs. 0.82), %AS (0.82 vs. 0.80), %PB (0.84 vs. 0.73), and plaque volume (0.84 vs. 0.79) when they were compared to IVUS, respectively.Fully automatic QCT analysis showed clinical utility compared with IVUS, as well as a compelling performance when compared with semiautomatic analyses.Coronary CTA enables the assessment of coronary atherosclerotic plaque.High-risk plaque characteristics and overall plaque burden can predict future cardiac events.Coronary atherosclerotic plaque quantification is currently unfeasible in practice.Quantitative computed tomography coronary plaque analysis software (QCT) enables feasible plaque quantification.Fully automatic QCT analysis shows excellent performance.