Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography
Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography
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DOI：
10.1016/j.ajo.2011.06.017
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发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Freedman, Sharon F.
中科院分区：
文献类型：
--
作者：
Cabrera, Michelle T.;Maldonado, Ramiro S.;Freedman, Sharon F.
目的：报告使用手持式谱域光学相干断层扫描 (SD OCT) 成像的健康新生儿的视网膜结果。设计：前瞻性、观察性病例系列。方法：在杜克出生中心，39 名足月新生儿在没有镇静的情况下，通过间接检眼镜进行散瞳视网膜检查，并通过手持式 SD OCT 进行视网膜成像。结果：在 39 名接受成像的婴儿中， 44% (17/39) 是男性。种族和民族构成为 56% 白人、38% 黑人、3% 亚裔和 3% 西班牙裔。中位孕龄为 39 周（范围：36 至 41 周）。 39 名婴儿中的 6 名（15%）在 SD OCT 上发现双侧黄斑中心凹下积液，但间接检眼镜检查未发现。 8 名婴儿 (21%) 在散瞳视网膜检查中发现视网膜出血，其中 1 名婴儿在 SD OCT 上发现视网膜下液。 1 至 4 个月后，SD OCT 随访检查发现视网膜下液已消退。与没有视网膜下积液的婴儿相比，有双侧视网膜下积液的婴儿的胎龄较长（中位数分别为 40.4 周和 39.1 周；P = .03），并且更有可能母亲患有糖尿病（分别为 2/6 和 0/33；P = .02）。阴道分娩与剖腹产分娩在两组之间没有显着差异。结论：一些健康足月婴儿的双侧中心凹下积液在散瞳视网膜检查中不明显。这种液体会在几个月内消失。这一发现的视觉意义尚不清楚，但临床医生应该意识到，在使用 SD OCT 评估新生儿的视网膜病理特征时，这种情况很常见。 （美国眼科杂志 2012 年；153：167-175。(C) 2012 年，Elsevier Inc. 保留所有权利。）
PURPOSE: To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT).DESIGN: Prospective, observational case series.METHODS: Thirty-nine full-term newborn infants underwent dilated retinal examinations by indirect ophthalmoscopy and retinal imaging by handheld SD OCT, without sedation, at the Duke Birthing Center.RESULTS: Of the 39 infants imaged, 44% (17/39) were male. Race and ethnicity composition was 56% white, 38% black, 3% Asian, and 3% Hispanic. Median gestational age was 39 weeks (range, 36 to 41 weeks). Six (15%) of the 39 infants had bilateral subfoveal fluid on SD OCT not seen by indirect ophthalmoscopy. Eight infants (21%) had retinal hemorrhages noted on dilated retinal examination, 1 of which had subretinal fluid on SD OCT. Subretinal fluid was noted on follow-up examination to have resolved on SD OCT 1 to 4 months later. Infants with bilateral subretinal fluid had an older gestational age compared with infants without subretinal fluid (median, 40.4 vs 39.1 weeks, respectively; P = .03) and were more likely to have had mothers with diabetes (2/6 vs 0/33, respectively; P = .02). Vaginal versus Caesarian section delivery was not significantly different between the 2 groups.CONCLUSIONS: Some healthy full-term infants have bilateral subfoveal fluid not obvious on dilated retinal examination. This fluid resolves within several months. The visual significance of this finding is unknown, but clinicians should be aware that it is common when evaluating newborn infants for retinal pathologic features using SD OCT. (Am J Ophthalmol 2012;153:167-175. (C) 2012 by Elsevier Inc. All rights reserved.)