Elevated threshold for thyrotropin suppression in congenital hypothyroidism.
Elevated threshold for thyrotropin suppression in congenital hypothyroidism.
复制标题
先天性甲状腺功能减退症促甲状腺素抑制阈值升高。
DOI：
10.1001/archpedi.1980.02130130011004
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. Macgillivray
中科院分区：
文献类型：
--
作者：
R. M. Schultz;M. Glassman;M. Macgillivray
五名先天性甲状腺功能减退症的婴儿在服用足够剂量的甲状腺素后，发现血清促甲状腺激素（TSH）水平持续升高6至24个月。在这些婴儿中，甲状腺素抑制TSH的下丘脑-垂体阈值似乎异常高。这些观察结果表明，血清TSH水平不应该是唯一的标准，以评估充分的甲状腺激素替代治疗的最初几个月的先天性甲状腺功能减退症。
Five infants with congenital hypothyroidism were found to have persistently elevated levels of serum thyrotropin (TSH) for six to 24 months after administration of adequate doses of thyroxine. In these infants, the hypothalamic-pituitary threshold for TSH suppression by thyroxine seems to be unusually high. These observations suggest that serum TSH levels should not be the sole criterion for evaluating adequacy of thyroid hormone replacement during the initial months of therapy for congenital hypothyroidism.