A prospective Swedish study on body size, body composition, diabetes, and prostate cancer risk.
A prospective Swedish study on body size, body composition, diabetes, and prostate cancer risk.
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DOI：
10.1038/sj.bjc.6605077
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发表时间：
2009-06-02
影响因子：
8.8
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中科院分区：
文献类型：
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肥胖可能与前列腺癌（PCa）的风险增加有关。根据一种假设，肥胖可以降低非侵袭性肿瘤的风险，同时增加侵袭性癌症的风险。此外，中心性肥胖可能与PCa风险独立相关;它也与糖尿病相关，糖尿病本身可能影响PCa的风险。我们在基于人群的马尔默饮食和癌症队列的10564名最初无癌症的男性（年龄45-73岁）中研究了身高、身体成分和脂肪分布、糖尿病患病率与总的、侵袭性和非侵袭性PCa风险之间的关系。由研究护士进行人体测量和身体成分测量，包括用于估计脂肪量的生物电阻抗。糖尿病患病率是自我报告的。癌症病例和临床特征通过国家和地区登记数据确定。饮食和其他背景数据通过改良的饮食史方法和广泛的问卷调查获得。在平均随访11.0年期间，诊断出817例偶发PCa病例。其中，281人被列为侵略性。有202例发生在65岁之前。身高与总的和非侵袭性PCa风险呈正相关。腰臀比（WHR）是一种中心性肥胖的测量指标，在65岁之前与PCa呈正相关，与总PCa的相关性较弱。这种关联与体重指数（BMI）和其他潜在混杂因素无关。以BMI或体脂百分比表示的全身肥胖和普遍的糖尿病与PCa风险无关。在这项研究中，腰臀比和身高是比一般肥胖更强的PCa预测因子。
Obesity may be associated with increased risk of prostate cancer (PCa). According to one hypothesis, obesity could lower the risk of non-aggressive tumours, while simultaneously increasing the risk of aggressive cancer. Furthermore, central adiposity may be independently associated with PCa risk; it is also associated with diabetes, which itself may influence risk of PCa. We studied the associations between height, body composition, and fat distribution, diabetes prevalence and risk of total, aggressive, and non-aggressive PCa in 10 564 initially cancer-free men (aged 45–73 years) of the population-based Malmö Diet and Cancer cohort. Anthropometric and body composition measurements, including bioelectrical impedance for estimation of fat mass, were performed by study nurses. Diabetes prevalence was self-reported. Cancer cases and clinical characteristics were ascertained through national and regional registry data. Dietary and other background data were obtained through a modified diet history method and an extensive questionnaire. During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Of these, 281 were classified as aggressive. There were 202 cases occurring before 65 years of age. Height was positively associated with total and non-aggressive PCa risk. Waist–hip ratio (WHR), a measure of central adiposity, was positively associated with PCa before age 65, and less strongly, with total PCa. This association was independent of body mass index (BMI) and other potential confounders. General adiposity, expressed as BMI or body fat percentage, and prevalent diabetes were not associated with PCa risk. In this study, WHR and body height were stronger PCa predictors than general adiposity.