TRANSFERRIN RECEPTOR ON ENDOTHELIUM OF BRAIN CAPILLARIES
TRANSFERRIN RECEPTOR ON ENDOTHELIUM OF BRAIN CAPILLARIES
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DOI：
10.1038/312162a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
MASON, DY
中科院分区：
文献类型：
--
作者：
JEFFERIES, WA;BRANDON, MR;MASON, DY
血脑屏障防止蛋白质和代谢物从脑血管被动扩散到神经元和神经胶质细胞周围的组织空间。为了给这些细胞提供营养，必须存在代谢物的运输机制，而且这种机制已经得到证实。我们现在表明，针对大鼠和人转铁蛋白受体的单克隆抗体可以标记大脑中的毛细血管，但不能标记其他组织。在大鼠中，这种标记发生在将抗体注射到血液中之后，因此受体似乎可以在内皮细胞表面接触到。有可能在这些细胞上表达转铁蛋白受体，从而允许转铁蛋白（以及铁）运输到脑组织中。
The blood/brain barrier prevents the passive diffusion of proteins and metabolites from cerebral blood vessels into tissue spaces around neuronal and glial cells. To provide nutrients for these cells, transport mechanisms must exist and indeed have been demonstrated for metabolites1. We now show that monoclonal antibodies against rat and human transferrin receptors label blood capillaries in the brain but not in other tissues. In the rat this labelling occurs after injection of antibody into the blood, thus the receptors seem to be accessible at the endothelial surface. It is possible that transferrin receptors are expressed on these cells to allow transport of transferrin (and thus iron) into brain tissues.