Effect of skin allograft immunization on the mixed leukocyte reaction of the clawed frog, Xenopus laevis.
Effect of skin allograft immunization on the mixed leukocyte reaction of the clawed frog, Xenopus laevis.
复制标题
皮肤同种异体移植免疫对爪蛙混合白细胞反应的影响。
DOI：
10.1097/00007890-198110000-00004
复制
发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
Cohen,N
中科院分区：
文献类型：
--
作者：
Barlow,EH;Cohen,N
采用单向混合白细胞反应(MLRs)检测了非洲爪蛙(Xenopus Laevis)对皮肤移植物的反应。含有来自移植受体的应答细胞和来自移植供者的刺激细胞的培养物的最大和中位刺激指数(SIS)显著大于来自对照、非免疫动物的应答脾细胞的培养物的最大和中位刺激指数(SIS)。在更多涉及免疫反应细胞的培养中，也比对照培养更早(培养第2天)记录到显著的刺激。MLR中较早和较大的增殖是抗原特异性的。
One-way mixed leukocyte reactions (MLRs) of responder spleen cells from frogs (Xenopus laevis) that had rejected skin grafts were examined. Maximum and median stimulation indices (SIs) of cultures that contained responder cells from the graft recipient and stimulator cells from the graft donor were significantly greater than the peak and median SIs of cultures in which the responder splenocytes were from control, non-immune animals. Significant stimulation was also recorded earlier (day 2 of culture) in more cultures involving immune responder cells than in control cultures. This earlier and greater proliferation in MLR was antigen specific.