Intrinsic thalamocortical connectivity varies in the age of onset subtypes in major depressive disorder
Intrinsic thalamocortical connectivity varies in the age of onset subtypes in major depressive disorder
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DOI：
10.2147/ndt.s184425
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发表时间：
2019-01-01
影响因子：
3.2
通讯作者：
Ramasubbu, Rajamannar
中科院分区：
文献类型：
--
作者：
Brown, Elliot C.;Clark, Darren L.;Ramasubbu, Rajamannar
背景：重性抑郁症（MDD）患者的丘脑皮质系统存在差异。鉴于先前的证据表明，表型异质性的发病年龄在MDD，我们研究是否在丘脑皮质连接的差异可以确定生物亚型的MDD定义的发病年龄onset.Methods：共94例，包括20早发性（EO）MDD（发病，18岁），34成人发病（AO）MDD，和40名健康对照（HC）进行了静息状态功能MRI。血氧水平依赖性的时间过程中提取的6个皮层区域的利益（ROls）组成的额叶，颞叶，顶叶，枕叶和中央前回和中央后回。结果：方差分析结果显示，在额颞部与丘脑的连接中，组间主效应显著。与HC相比，AO-MDD组的前丘脑-丘脑低连通性较好，而EO-MDD组的前丘脑-丘脑低连通性较差。然而，EO-MDD和AO-MDD之间的直接比较显示无差异。此外，相对于HC，EO-MDD和AO-MDD患者均存在右侧颞-丘脑超连通性。这些结果不占性别，年龄，或疾病burners.Conclusion：发病年龄可能是MDD的额丘脑内在连接的异质性的来源。
Background: Differences in the thalamocortical system have been shown in patients with major depressive disorder (MDD). Given prior evidence of phenotypic heterogeneity by the age of onset in MDD, we examined whether differences in thalamocortical connectivity could identify biological subtypes of MDD defined by the age of illness onset.Methods: A total of 94 subjects including 20 early-onset (EO) MDD (onset, 18 years), 34 adult-onset (AO) MDD, and 40 healthy controls (HCs) underwent resting-state functional MRI. Blood-oxygen-level-dependent time courses were extracted from six cortical regions of interest (ROls) consisting of frontal, temporal, parietal, and occipital lobes and precentral and postcentral gyri. Each ROI 's time course was then correlated with each voxel in thalamus, while covarying out signal from every other ROI.Results: The analysis of variance results showed significant main effects of group in frontal and temporal connectivity with thalamus. Group contrasts showed aright Pronto-thalamic hypo-connectivity only in AO-MDD, but not in EO-MDD, when compared to HCs. However, direct comparison between EO-MDD and AO-MDD showed no differences. Furthermore, there was a right temporal-thalamic hyperconnectivity in both EO-MDD and AO-MDD patients relative to HCs. These results were not accounted for by sex, age, or illness burden.Conclusion: The age of illness onset may be a source of heterogeneity in fronto-thalamic intrinsic connectivity in MDD.