Eye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients.
Eye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients.
复制标题
谱系人格障碍中的眼球运动：社区受试者和精神分裂症患者亲属的比较。
DOI：
10.1176/ajp.153.3.362
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ross,DE
中科院分区：
文献类型：
--
作者：
Thaker,GK;Cassady,S;Adami,H;Moran,M;Ross,DE
本研究的目的是在精神分裂症患者的家庭成员中测试眼动异常与精神分裂症谱系人格症状之间的关联的特异性。精神分裂症的遗传易感性的生物学标记的研究，其中测试的生物学措施和精神分裂症谱的人格症状之间的关联，受到限制，因为这些人格症状可能缺乏特异性的精神分裂症的表型。行为测量和这些人格症状之间的关联通常很容易是错误的（即与精神分裂症的脆弱性无关）。相反，在没有已知精神分裂症病史的谱系受试者中存在相对正常的发现，使生物行为测量成为此类调查的有趣候选者。方法从社区招募的75名没有精神病家族史的受试者完成了这项研究（75人中有24人有明显的精神分裂症谱系人格症状）。32名精神分裂症患者的一级亲属（13名有谱系症状）完成了这项研究。受试者年龄为18-45岁，没有DSM-III-R轴I diagnosis.ResultsQualitative smooth pursuit eye movement score显着差的频谱症状的亲属比频谱受试者没有精神分裂症家族史和nonspectrum亲属。分裂型和分裂样症状解释了亲属中眼动追踪测量的显着差异（分别为31%和20%），但在社区受试者中则不然（不到2%）。精神分裂症患者的亲属和没有频谱症状有显着较长的antisaccade潜伏期，尽管类似的视觉引导扫视的潜伏期，than the community subjects.ConclusionsSmooth追求异常的精神分裂症谱系人格障碍的受试者是特别与精神分裂症的家族史。
ObjectiveThe purpose of the current study was to test the specificity of an association between eye tracking abnormality and schizophrenia spectrum personality symptoms in the family members of schizophrenic patients. The studies of biological markers for genetic vulnerability to schizophrenia, which test an association between a biological measure and schizophrenia spectrum personality symptoms, are constrained, since these personality symptoms may lack the specificity for a schizophrenic phenotype. An association between a behavioral measure and these personality symptoms in general can easily be false (ie, not related to schizophrenic vulnerability). In contrast, a strong deviant finding in the relatives of schizophrenic patients with spectrum personality symptoms, in the presence of a relatively normal finding in spectrum subjects without a known history of schizophrenia, makes the biobehavioral measure an interesting candidate for such investigations.MethodSeventy-five subjects recruited from the community who did not have a family history of psychosis completed the study (24 of the 75 had significant schizophrenia spectrum personality symptoms). Thirty-two first-degree relatives of schizophrenic patients (13 with spectrum symptoms) completed the study. Subjects were 18-45 years old and had no DSM-III-R axis I diagnosis.ResultsQualitative smooth pursuit eye movement score was significantly worse in relatives with the spectrum symptoms than in spectrum subjects without a family history of schizophrenia and the nonspectrum relatives. Schizotypal and schizoid symptoms explained a significant amount of the variance in the eye tracking measure in the relatives (31% and 20%, respectively) but not in the community subjects (less than 2%). Relatives of schizophrenic patients with and without the spectrum symptoms had significantly longer antisaccade latency, in spite of comparable latency for visually guided saccades, than the community subjects.ConclusionsSmooth pursuit abnormality in subjects with schizophrenia spectrum personality disorders is specifically associated with a family history of schizophrenia.