EXCESS FUNCTION HAIRY-WING MUTATIONS CAUSED BY GYPSY AND COPIA INSERTIONS WITHIN STRUCTURAL GENES OF THE ACHAETE-SCUTE LOCUS OF DROSOPHILA
EXCESS FUNCTION HAIRY-WING MUTATIONS CAUSED BY GYPSY AND COPIA INSERTIONS WITHIN STRUCTURAL GENES OF THE ACHAETE-SCUTE LOCUS OF DROSOPHILA
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DOI：
10.1016/0092-8674(86)90764-6
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发表时间：
1986-01-31
期刊：
影响因子：
64.5
通讯作者：
MODOLELL, J
中科院分区：
文献类型：
--
作者：
CAMPUZANO, S;BALCELLS, L;MODOLELL, J
毛翅(HW)突变导致果蝇角质层上额外毛状体的分化。它们与achaete-scute复合体的修饰有关，在所研究的突变体中，该复合体由可转座元件Gypsy(HW1，HWBS)或Copia(HwUa)的插入组成。吉普赛人和Copia分别插入无毛类和Scute转录区。插入-分裂基因的转录开始于正常位置，但终止于转座元件序列。吉普赛人体内截短的RNA比野生型果蝇中的同源物丰富5-20倍。在携带su(HW)突变的HW1返回体和HW1库中，丰度降低。这些和其他数据表明，HW突变的过量功能表型是由无毛或鳞状转录本的增加所产生的。
Hairy-wing (Hw) mutations cause the differentiation of extra chaetes on the cuticle of Drosophila. They are associated with modifications of the achaete-scute complex that consist, in the mutants studied, of insertions of the transposable elements gypsy (Hw1, HwBS) or copia (HwUa). gypsy and copia are inserted in achaete and scute transcribed regions, respectively. Transcription of the insertion-splite genes starts at the normal site but terminates within the transposable element sequences. The RNA truncated within gypsy is 5-20 times more abundant than its homolog in wild-type flies. The abundance is reduced in Hw1 revertants and Hw1 stocks carrying su(Hw) mutations. These and other data suggest that the excess function phenotypes of Hw mutations are generated by an increase in achaete or scute transcripts.