Motor performance and behavior of immature rats are not compromised by a high dose of topiramate
Motor performance and behavior of immature rats are not compromised by a high dose of topiramate
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DOI：
10.1016/j.yebeh.2005.04.013
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发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Mares, P
中科院分区：
文献类型：
--
作者：
Alaverdashvili, M;Kubová, H;Mares, P
托吡酯对未成熟大鼠可能的认知副作用研究的第一步是确定托吡酯（TPM）是否以及如何影响运动能力和自发行为。因此，我们使用适合年龄的测试研究了TPM对12日龄和25日龄大鼠运动表现的影响。野外自发行为仅在25日龄的动物中进行研究。TPM按80和/或160 mg/kg腹腔注射；对照组大鼠注射溶剂（二甲亚砜）。在给药前、给药后1、3和24小时进行一系列电机测试；在TPM给药后2小时和24小时记录野外行为。TPM对电机性能的影响与溶剂相似。在12天大的大鼠中，仅在3小时的间隔中发现了一些差异。在开放领域的行为没有受到TPM的影响；相反，观察到明显的抗焦虑作用。习惯化（在5分钟观察期间运动活动减少）是一种简单的非联想学习形式，TPM也没有损害。单次高剂量的TPM只导致运动性能的短暂变化。在25日龄大鼠中观察到的可能的抗焦虑作用有待进一步研究。(c) 2005爱思唯尔公司版权所有。
The first step in a study of possible cognitive side effects of topiramate in immature rats is to determine if and how topiramate (TPM) influences motor ability and spontaneous behavior. We therefore studied the effects of TPM on motor performance of 12- and 25-day-old rats using age-appropriate tests. Spontaneous behavior in the open field was studied in 25-day-old animals only. TPM was administered intraperitoneally at 80 and/or 160 mg/kg; control rats were injected with solvent (dimethylsulfoxide). A battery of motor tests was conducted before and 1, 3, and 24 hours after administration; behavior in the open field was recorded 2 and 24 hours after TPM administration. The effects of TPM on motor performance were similar to those of solvent. A few differences were found only at the 3-hour interval in 12-day-old rats. Behavior in the open field was not impaired by TPM; on the contrary, an apparent anxiolytic effect was observed. Habituation (a decrease in locomotor activity during the 5-minute observation period), a form of simple nonassociative learning, was also not compromised by TPM. A single high dose of TPM resulted only in transient changes in motor performance. A possible anxiolytic effect observed in 25-day-old rats should be studied. (c) 2005 Elsevier Inc. All rights reserved.