Models and methods for analyzing DCE-MRI: A review
Models and methods for analyzing DCE-MRI: A review
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DOI：
10.1118/1.4898202
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发表时间：
2014-12-01
期刊：
影响因子：
3.8
通讯作者：
Dwyer, Amy C.
中科院分区：
文献类型：
--
作者：
Khalifa, Fahmi;Soliman, Ahmed;Dwyer, Amy C.
目的：要提出一个审查最常用的技术来分析动态对比增强磁共振成像（DCE-MRI），讨论他们的优点和缺点，并概述了最近的临床应用的结果从这些approaches.Methods：DCE-MRI允许无创定量分析造影剂（CA）在软组织中的瞬态。因此，它是一个重要的和完善的工具，以揭示微血管和灌注在各种临床应用。在过去的三十年中，已经开发了大量的非参数和参数模型和方法，以量化CA灌注到组织中，并从信号或浓度-时间曲线估计灌注相关参数（指数）。这些指标广泛应用于各种临床应用，用于不同疾病的检测、表征和治疗监测。回顾模型和技术在各种临床应用中的有希望的理论发现和实验结果表明，DCE-MRI是一种临床相关的成像模式，可用于不同疾病的早期诊断，如乳腺癌和前列腺癌，肾排斥反应，结论：用于DCE-MRI分析的非参数和参数方法都具有量化组织灌注的能力。(C)2014年美国医学物理学家协会。
Purpose: To present a review of most commonly used techniques to analyze dynamic contrastenhanced magnetic resonance imaging (DCE-MRI), discusses their strengths and weaknesses, and outlines recent clinical applications of findings from these approaches.Methods: DCE-MRI allows for noninvasive quantitative analysis of contrast agent (CA) transient in soft tissues. Thus, it is an important and well-established tool to reveal microvasculature and perfusion in various clinical applications. In the last three decades, a host of nonparametric and parametric models and methods have been developed in order to quantify the CA's perfusion into tissue and estimate perfusion-related parameters (indexes) from signal-or concentration-time curves. These indexes are widely used in various clinical applications for the detection, characterization, and therapy monitoring of different diseases.Results: Promising theoretical findings and experimental results for the reviewed models and techniques in a variety of clinical applications suggest that DCE-MRI is a clinically relevant imaging modality, which can be used for early diagnosis of different diseases, such as breast and prostate cancer, renal rejection, and liver tumors.Conclusions: Both nonparametric and parametric approaches for DCE-MRI analysis possess the ability to quantify tissue perfusion. (C) 2014 American Association of Physicists in Medicine.