THE INFLUENCE OF ESTROUS-CYCLE AND INTRASTRIATAL ESTRADIOL ON SENSORIMOTOR PERFORMANCE IN THE FEMALE RAT
THE INFLUENCE OF ESTROUS-CYCLE AND INTRASTRIATAL ESTRADIOL ON SENSORIMOTOR PERFORMANCE IN THE FEMALE RAT
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DOI：
10.1016/0091-3057(87)90476-x
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发表时间：
1987-05-01
影响因子：
3.6
通讯作者：
JENUWINE, MJ
中科院分区：
文献类型：
--
作者：
BECKER, JB;SNYDER, PJ;JENUWINE, MJ
动情周期和纹状体内植入17 β-雌二醇（17 β-雌二醇）的影响雌二醇）。17 α-雌二醇（17 α-雌二醇）或胆固醇对雌性大鼠穿越狭窄悬梁所造成的足错次数的影响。雌性大鼠在发情期的脚步错误比在周期的其他日子要少。当在亮：暗循环的亮或暗阶段进行测试时，这是真实的。纹状体内植入30%17 β-雌二醇6小时导致在激素植入后4小时就显著改善感觉运动性能，并持续数天。相比之下，30%17 α-γ-葡聚糖的纹状体内植入物可用于治疗癌症。雌二醇或胆固醇对性能没有影响。激素扩散离开植入套管的程度是最小的，并且产生的17 β-纹状体中雌二醇低于10 pg/mg。它的结论是，雌二醇有一个直接的，立体定向作用在纹状体，影响性能的熟练的运动行为在雌性大鼠。
The influence of estrous cycle and intrastriatal implants of 17beta-estradiol (17.beta.-estradiol). 17alpha-estradiol (17.alpha.-estradiol) or cholesterol on the number of footfaults made by female rats traversing a narrow suspended beam was investigated. Female rats made fewer footfaults on estrus than on other days of the cycle. This was true when testing occurred during either the light or dark phase of the light:dark cycle. Intrastriatal implants of 30% 17.beta.-estradiol for 6 hours resulted in a significant improvement in sensorimotor performance as soon as 4 hours after hormone implant and persisting for days. In contrast, intrastriatal implants of either 30% 17.alpha.-estradiol or cholesterol had no influence on performance. The extent of hormone diffusion away from the implant cannula was minimal, and the resulting concentration of 17.beta.-estradiol in the striatum was less than 10 pg/mg. It is concluded that estradiol has a direct, stereospecific effect in the striatum that influences performance of a skilled motor act in the female rat.