Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis
Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis
复制标题
DOI：
10.1183/09031936.00027412
复制
发表时间：
2013-11-01
影响因子：
24.3
通讯作者：
Selman, Moises
中科院分区：
文献类型：
--
作者：
Mendoza-Milla, Criselda;Valero Jimenez, Ana;Selman, Moises
特发性肺纤维化（IPF）是一种与年龄相关的肺部疾病，其特征是肌成纤维细胞群扩张和异常肺重塑。脱氢表雄酮（DHEA）是一种类固醇激素原，随着年龄的增长而下降，但在慢性退行性疾病中，DHEA的下降幅度过大。我们定量了137例IPF患者和58例对照者的血浆DHEA及其硫酸化形式（DHEA-S）水平，并检查了DHEA对人肺成纤维细胞的影响。男性IPF患者血浆DHEA/DHEA-S显著降低，（中位（范围）DHEA：4.4（0.2-29.2）vs 6.7（2.1-15.2）ng.mL（-1），p
Idiopathic pulmonary fibrosis (IPF) is an ageing-related lung disorder characterised by expansion of the myofibroblast population and aberrant lung remodelling. Dehydroepiandrosterone (DHEA), a steroid pro-hormone, decreases with age but an exaggerated decline has been associated with chronic degenerative diseases.We quantified the plasma levels of DHEA and its sulfated form (DHEA-S) in 137 IPF patients and 58 controls and examined the effects of DHEA on human lung fibroblasts.Plasma DHEA/DHEA-S was significantly decreased in male IPF patients (median (range) DHEA: 4.4 (0.2-29.2) versus 6.7 (2.1-15.2) ng.mL(-1), p