Prospective study of tooth loss and incident esophageal and gastric cancers in China
Prospective study of tooth loss and incident esophageal and gastric cancers in China
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DOI：
10.1023/a:1012290009545
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发表时间：
2001-11-01
影响因子：
2.3
通讯作者：
Dawsey, SM
中科院分区：
文献类型：
--
作者：
Abnet, CC;Qiao, YL;Dawsey, SM
目的：在一项前瞻性研究中，确定牙齿脱落与食管鳞状细胞癌、贲门腺癌或胃非贲门腺癌发生风险之间的关系。方法：采用考克斯比例风险回归对28，868人队列进行了5.25年的前瞻性随访。基线问卷包括关于牙齿脱落的问题，报告牙齿脱落的个体由研究人员对他们的牙齿进行计数。分析队列包括620食管，431贲门，和102胃非贲门癌cases.Results：牙齿损失与发展的所有三种癌症的风险显着升高。当检查中位数分裂时，牙齿脱落与食管1.3（1.1-1.6），贲门1.3（1.0-1.6）和胃非贲门1.8（1.1-3.0）的相对风险（RR）（95%置信区间，CI）相关。进一步的分析表明，这种增加的风险是最密切相关的损失的前几颗牙齿，并主要局限于我们的cohol.Conclusions的年轻成员：在这个队列牙齿损失的风险增加发展上消化道癌。我们推测这可能与口腔细菌植物群的改变以及随后体内致癌物如亚硝胺的产生增加有关。
Objective: To determine the association between tooth loss and the risk of developing esophageal squamous cell carcinoma, gastric cardia adenocarcinoma, or gastric non-cardia adenocarcinoma in a prospective study.Methods: Cox proportional hazards regression was used to examine these associations in a 28,868-person cohort followed prospectively for 5.25 years. The baseline questionnaire included questions regarding tooth loss, and individuals reporting lost teeth had their teeth counted by study personnel. The analytic cohort included 620 esophagus, 431 gastric cardia, and 102 gastric non-cardia cancer cases.Results: Tooth loss was associated with a significantly elevated risk of developing all three cancers. When examined as median splits, tooth loss was associated with a relative risk (RR) (95% confidence interval, CI) of 1.3 (1.1-1.6) in the esophagus, 1.3 (1.0-1.6) in the gastric cardia, and 1.8 (1.1-3.0) in the gastric non-cardia. Further analysis demonstrated that this increased risk was most strongly associated with the loss of the first few teeth and was primarily confined to the younger members of our cohort.Conclusions: In this cohort tooth loss increased the risk of developing upper gastrointestinal cancer. We hypothesize that this may be related to alterations in oral bacterial flora and subsequent increases in the in-vivo production of carcinogens such as nitrosamines.