Effects of Concomitant Stimulation of the GABAergic and Norepinephrine System on Inhibitory Control - A Study Using Transcutaneous Vagus Nerve Stimulation
Effects of Concomitant Stimulation of the GABAergic and Norepinephrine System on Inhibitory Control - A Study Using Transcutaneous Vagus Nerve Stimulation
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DOI：
10.1016/j.brs.2016.07.004
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发表时间：
2016-11-01
影响因子：
7.7
通讯作者：
Colzato, Lorenza
中科院分区：
文献类型：
--
作者：
Beste, Christian;Steenbergen, Laura;Colzato, Lorenza
背景：抑制性控制过程是一种中枢执行功能。几条证据表明，GABA能和去甲肾上腺素（NE）系统调节抑制性控制过程。然而，在GABA能和NE系统的活动抑制control.Objective/hypothesis的联合增加的影响还没有被检查：我们检查的联合影响的GABA和NE系统抑制control.Methods：我们使用经皮迷走神经刺激（tVNS），这已被证明调制GABA能和NE系统。结果：tVNS对后向抑制过程无影响，但对反应抑制过程有影响。然而，只有当工作记忆过程需要控制反应抑制时，这些才出现。与假刺激相比，tVNS诱导更好的反应抑制性能（即更少的假警报）。结论：伴随调制的GABA能和NE系统，由tVNS诱导，影响抑制控制过程，但只有当工作记忆过程中发挥重要作用的抑制控制。尽管GABA能和NE系统都受到tVNS的调制，但结果表明NE系统的调制对于新兴效应是最重要的。(C)2016 Elsevier Inc. All rights reserved.
Background: Inhibitory control processes are a central executive function. Several lines of evidence suggest that the GABAergic and the norepinephrine (NE) system modulate inhibitory control processes. Yet, the effects of conjoint increases in the GABAergic and NE system activity on inhibitory control have not been examined.Objective/hypothesis: We examine the conjoint effects of the GABA and NE system for inhibitory control.Methods: We used transcutaneous vagus nerve stimulation (tVNS), which has been shown to modulate both the GABAergic and NE system. We examine the effects of tVNS in two experimental paradigms examining different aspect of inhibitory control; i.e. a backward inhibition paradigm and a response inhibition paradigm modulating working memory load.Results: There were no effects of tVNS on backward inhibition processes, but on response inhibition processes. Yet, these only emerged when working memory processes were needed to control response inhibition. Compared to a sham stimulation, tVNS induced better response inhibition performance (i.e. fewer false alarms).Conclusions: A concomitant modulation of the GABAergic and NE system, as induced by tVNS, affects inhibitory control processes, but only when working memory processes play an important role for inhibitory control. Even though both the GABAergic and the NE system are modulated by tVNS, the results suggest that the modulation of the NE system is most important for the emerging effects. (C) 2016 Elsevier Inc. All rights reserved.