Osteoporosis: an evolutionary perspective.
Osteoporosis: an evolutionary perspective.
复制标题
骨质疏松症：进化的角度。
DOI：
10.1007/s00439-008-0559-8
复制
发表时间：
2008
期刊：
影响因子：
5.3
通讯作者：
Karasik,David
中科院分区：
文献类型：
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作者：
Karasik,David
预期寿命的延长导致人口总体老龄化和老年人口数量增加。因此，骨质疏松症患者数量大幅增加，髋部骨折也随之流行。骨质疏松症是一种与年龄相关的全身性疾病，在哺乳动物中自然发生，仅在人类中发生。众所周知，骨质疏松症具有高度遗传性。然而，假设这种后生殖疾病从一代传到下一代的遗传决定因素是违反直觉的，那么根据人类进化的原理，我将尝试从进化、选择和人类环境变化的角度来解释这一现象，这有助于人类长寿，但另一方面，也导致了包括骨质疏松症在内的文明疾病。有必要深入研究人类物种的进化，寻找人类在过去几千年中所处的特定环境的适应模式，以澄清“好”和“坏”基因是否存在，以及如何找到和纠正它们。上述问题的答案将帮助我们确定当前骨质疏松症流行的原因，并确定针对性的治疗方法。
Increased life expectancy has led to an overall aging of the population and greater numbers of elderly people. Therefore, the number of people with osteoporosis has increased substantially, accompanied with an epidemic of hip fractures. Osteoporosis is an age-related systemic condition that naturally occurs, among mammals, only in humans. Osteoporosis is known to be highly heritable. However, assuming a genetic determinant for this post-reproductive disease to be transmitted from one generation to the next is counter-intuitive, based on the principles of human evolution, I will attempt to provide an explanation of the phenomenon from the point of view of evolution, selection, and changed environment in humans, which contributed to human longevity, while on other hand, contribute to diseases of civilization, including osteoporosis. There is a need to delve into evolution of human species in search for adaptive patterns to a specific environment that humans are operating in the last couple of millennia, to clarify whether “good” and “bad” genes exist, and how to find and correct them. The answer to the above questions will help us to identify causes of the current epidemic of osteoporosis and to pin-point a tailored treatment.