Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden
Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden
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DOI：
10.1183/13993003.00477-2016
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发表时间：
2016-12-01
影响因子：
24.3
通讯作者：
Askling, Johan
中科院分区：
文献类型：
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作者：
Arkema, Elizabeth V.;Grunewald, Johan;Askling, Johan
我们的目的是利用瑞典基于人群的登记数据估计结节病的当代发病率和流行率。从国家患者登记册（1964-2013年住院和2001-2013年门诊）中确定任何结节病编码访问的成年人。人口统计和药物分配数据从国家登记册中检索。我们估计了2013年结节病的总体患病率和居住县。2003-2012年结节病发病率按性别、年龄、教育程度和诊断年份进行估计。病例定义不同，以检验其稳健性。2013年有超过16000人有结节病病史。当定义为两次或两次以上结节病编码就诊时，患病率为每10万人160例。使用不同的定义，患病率从每10万人中152人（需要专家就诊）到215人（只需要一次就诊）不等。发病率最高的是北部人口密度较低的县。发病率为每年每10万人11.5例，根据病例定义变化-10%至+30%。发病率在30-50岁男性和50-60岁女性中最高，但受教育程度不存在差异，且随时间稳定。本研究是使用基于人群的个体水平数据对结节病进行的最大规模流行病学调查。男性的诊断年龄比女性小10岁，且存在地域差异。
Our objective was to estimate the contemporary incidence and prevalence of sarcoidosis using Swedish population-based register data.Adults with any sarcoidosis-coded visit were identified from the National Patient Register (hospitalisations 1964-2013 and outpatient care 2001-2013). Demographic and medication dispensing data were retrieved from national registers. We estimated the prevalence of sarcoidosis in 2013 overall and by county of residence. The incidence of sarcoidosis during 2003-2012 was estimated by sex, age, education level and year of diagnosis. Case definitions were varied to test their robustness.More than 16000 individuals had a history of sarcoidosis in 2013. When defined as two or more sarcoidosis-coded visits, the prevalence was 160 per 100 000. Using different definitions, the prevalence ranged from 152 (requiring a specialist visit) to 215 per 100 000 (only one visit required). The highest prevalence was observed in northern less densely populated counties. The incidence was 11.5 per 100 000 per year and varied by -10% to +30% depending on case definition. The incidence peaked in males aged 30-50 years and in females aged 50-60 years, but did not differ by education level and was stable over time.This study represents the largest epidemiological investigation of sarcoidosis using population-based individual-level data. Age at diagnosis in men was 10 years younger than in women and geographical variation was observed.