Biocompatibility of poly(carbonate urethane)s with various degrees of nanophase separation
Biocompatibility of poly(carbonate urethane)s with various degrees of nanophase separation
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DOI：
10.1002/mabi.200400163
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发表时间：
2005-03-15
影响因子：
4.6
通讯作者：
Kao, YC
中科院分区：
文献类型：
--
作者：
Hsu, SH;Kao, YC
纳米相分离已被认为影响聚氨酯的生物性能。在以前的工作（Macromol。Biosci. 2004，4891），合成并表征了六种不同的基于4，4 '-二苯基甲烷二异氰酸酯（MDI）的聚（碳酸酯氨基甲酸酯）（PCU），其表现出不同程度的纳米相分离。在目前的工作中，这些PCU被用作模型系统，研究纳米结构对聚氨酯生物相容性的影响。体外研究了PCU对人血小板活化、单核细胞活化、蛋白吸附和细菌粘附的影响。结果发现，人I、血小板以及单核细胞在PCU表面上较少活化，通常具有更大程度的纳米相分离。这一现象是密切相关的竞争吸附在这些表面上的人纤维蛋白原/白蛋白的比例较低。在一些纳米相分离的PCU中，细菌粘附也被抑制。（图）这里研究的PCU上的血小板形态。
Nanophase separation has been suggested to influence the biological performance of polyurethane. In a previous work (Macromol. Biosci. 2004, 4 891), six different 4,4'-diphenylmethane diisocyanate (MDI)-based poly(carbonate urethane)s (PCUs) that exhibited various degrees of nanophase separation were synthesized and characterized. In the present work, these PCUs were used as a model system to study the effect of nanometric structures on the biocompatibility of polyurethane. Human blood platelet activation, monocyte activation, protein adsorption, and bacterial adhesion on PCU were investigated in vitro. It was found that human I, blood platelets as well as monocytes were less activated on the PCU surfaces with a greater degree of nanophase separation in general. This phenomenon was closely associated with the lower ratio of human fibrinogen/albumin competitively adsorbed on these surfaces. Bacterial adhesion was also inhibited in some nanophase-separated PCUs.(GRAPHIC)The morphology of a platelet on a PCU studied here.