Consumption of sugar-sweetened and artificially sweetened soft drinks and risk of obesity-related cancers
Consumption of sugar-sweetened and artificially sweetened soft drinks and risk of obesity-related cancers
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DOI：
10.1017/s1368980017002555
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发表时间：
2018-06-01
影响因子：
3.2
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
--
作者：
Hodge, Allison M.;Bassett, Julie K.;Giles, Graham G.
目的：验证这样一种假设，即更频繁地饮用含糖软饮料会增加肥胖相关癌症的风险。为了进行比较，对人工加糖软饮料的相关性进行了评估。设计：通过与癌症登记的关联来确定癌症的前瞻性队列研究。在基线时，参与者完成了一份包含121项的FFQ，其中包括关于他们在过去一年中喝了加糖或人工加糖软饮料的次数的单独问题。他们测量了包括腰围在内的人体尺寸，并回答了有关吸烟、休闲体育活动和酒精饮料摄入量的问题。背景：墨尔本合作队列研究(MCCS)是一项前瞻性队列研究，在1990至1994年间招募了41514名年龄在40-69岁的男性和女性。第二波数据收集发生在2003-2007年。研究对象：35593名受试者患上3283例肥胖相关癌症的数据被纳入主要分析。结果：在基线时，饮用加糖软饮料和人工加糖软饮料的频率增加与腰围增加相关。对于含糖软饮料，肥胖相关癌症的风险比(HR)随着消费频率的增加而增加(1/d和1/月的HR=1.18；95%CI 0.97，1.45；P-趋势=0.007)。对于人工加糖的软饮料，肥胖相关癌症的HR与消费量无关(HR为消费量>；1/d V.
Objective: To test the hypothesis that more frequent consumption of sugar-sweetened soft drinks would be associated with increased risk of obesity-related cancers. Associations for artificially sweetened soft drinks were assessed for comparison.Design: Prospective cohort study with cancers identified by linkage to cancer registries. At baseline, participants completed a 121-item FFQ including separate questions about the number of times in the past year they had consumed wsugar-sweetened or artificially sweetened soft drinks. Anthropometric measurements, including waist circumference, were taken and questions about smoking, leisure-time physical activity and intake of alcoholic beverages were completed.Setting: The Melbourne Collaborative Cohort Study (MCCS) is a prospective cohort study which recruited 41 514 men and women aged 40-69 years between 1990 and 1994. A second wave of data collection occurred in 2003-2007. Subjects: Data for 35 593 participants who developed 3283 incident obesity-related cancers were included in the main analysis.Results: Increasing frequency of consumption of both sugar-sweetened and artificially sweetened soft drinks was associated with greater waist circumference at baseline. For sugar-sweetened soft drinks, the hazard ratio (HR) for obesity-related cancers increased as frequency of consumption increased (HR for consumption >1/d v. < 1/month = 1.18; 95% CI 0.97, 1.45; P-trend=0.007). For artificially sweetened soft drinks, the HR for obesity-related cancers was not associated with consumption (HR for consumption >1/ d v.