Slow-Release RGD-Peptide Hydrogel Monoliths
Slow-Release RGD-Peptide Hydrogel Monoliths
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DOI：
10.1021/la302071e
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发表时间：
2012-08-28
期刊：
影响因子：
3.9
通讯作者：
Connon, Che
中科院分区：
文献类型：
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作者：
Castelletto, Valeria;Hamley, Ian W.;Connon, Che
我们报告形成的水凝胶整料形成的功能化肽Fmoc-RGD（Fmoc：芴甲氧羰基）含有的RGD细胞粘附三肽基序。该单块在水中稳定近40天。凝胶整料呈现由肽纤维网络组成的刚性多孔结构。RGD修饰的肽纤维具有β折叠二级结构。我们证明，Fmoc-RGD整料可用于释放和封装材料，包括模型亲水性染料和药物化合物。我们提供了第一个洞察这种新材料的吸收和释放动力学之间的相关性，并表明这两个过程发生在类似的时间尺度。
We report on the formation of hydrogel monoliths formed by functionalized peptide Fmoc-RGD (Fmoc: fluorenylmethoxycarbonyl) containing the RGD cell adhesion tripeptide motif. The monolith is stable in water for nearly 40 days. The gel monoliths present a rigid porous structure consisting of a network of peptide fibers. The RGD-decorated peptide fibers have a beta-sheet secondary structure. We prove that Fmoc-RGD monoliths can be used to release and encapsulate material, including model hydrophilic dyes and drug compounds. We provide the first insight into the correlation between the absorption and release kinetics of this new material and show that both processes take place over similar time scales.