The association between parity and spontaneous preterm birth: a population based study
The association between parity and spontaneous preterm birth: a population based study
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DOI：
10.1186/s12884-020-02940-w
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发表时间：
2020-04-21
影响因子：
3.1
通讯作者：
Ravelli, Anita C. J.
中科院分区：
文献类型：
--
作者：
Koullali, Bouchra;van Zijl, Maud D.;Ravelli, Anita C. J.
背景早产是世界范围内围产儿死亡和新生儿发病率的主要原因。很多因素都与早产有关，包括产次。本研究的目的是调查产次与自然早产风险之间的关系。方法我们进行了一项回顾研究，包括从2010年到2014年荷兰第一次、第二次、第三次、第四次或第五次怀孕的妇女的活产单胎(>；=22周)。我们的主要结局是自然早产的风险&37周。次要结局为自然早产32周和28周。结果我们研究了802,119例妊娠，包括自然终止37周的30,237例。我们发现，与第二次怀孕的妇女相比，未分娩妇女(OR 1.95，95%CI 1.89-2.00)和第五次妊娠妇女(OR 1.26，95%CI 1.13-1.41)自然早产和37周的风险增加。自然早产32周和28周也有类似的结果。结论我们的数据显示未足月与自然早产&37、32和28周独立相关。此外，我们观察到，在第五次怀孕的妇女中，自然早产的风险增加，其中在早孕年龄早产的风险最高。
Background Preterm birth is the leading cause of perinatal mortality and neonatal morbidity worldwide. Many factors have been associated with preterm birth, including parity. The aim of the present study was to investigate associations between parity and risk of spontaneous preterm birth. Methods We conducted a retrospective study including live singleton births (>= 22 weeks) of women with a first, second, third, fourth or fifth pregnancy in The Netherlands from 2010 through 2014. Our primary outcome was risk of spontaneous preterm birth < 37 weeks. Secondary outcomes were spontaneous preterm birth < 32 and < 28 weeks. Results We studied 802,119 pregnancies, including 30,237 pregnancies that ended spontaneously < 37 weeks. We identified an increased risk for spontaneous preterm birth < 37 weeks in nulliparous women (OR 1.95, 95% CI 1.89-2.00) and women in their fifth pregnancy (OR 1.26, 95% CI 1.13-1.41) compared to women in their second pregnancy. Similar results were seen for spontaneous preterm birth < 32 and < 28 weeks. Conclusion Our data show an independent association between nulliparity and spontaneous preterm birth < 37, < 32 and < 28 weeks. Furthermore, we observed an increased risk for spontaneous preterm birth in women in their fifth pregnancy, with highest risk for preterm birth at early gestational age.