The relation of physical activity to cardiovascular disease risk factors in Mauritians. Mauritius Noncommunicable Disease Study Group.
The relation of physical activity to cardiovascular disease risk factors in Mauritians. Mauritius Noncommunicable Disease Study Group.
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毛里求斯人体力活动与心血管疾病危险因素的关系。
DOI：
10.1093/oxfordjournals.aje.a116161
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发表时间：
1991
影响因子：
5
通讯作者：
Chitson,P
中科院分区：
文献类型：
--
作者：
Zimmet,PZ;Collins,VR;Dowse,GK;Alberti,KG;Tuomilehto,J;Gareeboo,H;Chitson,P
作者调查了4658名年龄在25-74岁之间的亚洲印度人、克里奥尔人和中国人的随机样本中身体活动与心血管疾病风险因素之间的关系。已知患有糖尿病的受试者被排除在分析之外。受试者被分为“活跃”和“不活跃”组，这是根据在访谈时（1987年4月）确定的休闲和职业体力活动综合评分进行的。两小时血糖浓度和空腹和2小时血清胰岛素浓度显着较低，高密度脂蛋白（HDL）胆固醇显着较高的活跃受试者的两种性别。血浆尿酸和空腹甘油三酯水平也较低的活跃的受试者，但显着只有在女性。收缩压和舒张压水平，身体质量指数（体重（kg）/身高（m）2），腰臀比在两个活动组之间变化不大。在多元线性回归分析中，体力活动对雄性和雌性动物的2小时血糖和胰岛素以及雄性动物的空腹胰岛素模型产生了独立的负贡献。当不包括葡萄糖和胰岛素时，体力活动也对雌性动物的血浆甘油三酯模型（反向）和雄性动物的HDL胆固醇和HDL胆固醇占总胆固醇的比例（正向）做出了独立贡献。作者已经证明了改善心血管疾病的概况与体力活动在哥伦比亚。这些数据表明，大部分的影响是通过对胰岛素-葡萄糖代谢的影响来调节的。促进运动应成为预防这一人群心血管疾病和葡萄糖耐受不良的重要策略。
The authors investigated the relation between physical activity and cardiovascular disease risk factors in a random sample of 4, 658 Asian Indian, Creole, and Chinese adults aged 25–74 years from the island nation of Mauritius. Subjects known to have diabetes were excluded from analyses Subjects were divided into “active” and “inactive” groups on the basis of a combined leisure and occupational physical activity score determined at interview (April 1987). Two-hour plasma glucose concentration and fasting and 2-hour serum insulin concentrations were significantly lower and high density lipoprotein (HDL) cholesterol was significantly higher in active subjects of both sexes. Plasma uric acid and fasting triglyceride levels were also lower among active subjects, but significantly so only in females. Systolic and diastolic blood pressure levels, body mass index (weight (kg)/height (m)2), and waist:hip ratio varied little between the two activity groups. In multiple linear regression analyses, physical activity made an independent negative contribution to the models for 2-hour glucose and insulin in both males and females, as well as for fasting insulin in males. When glucose and insulin were not included, physical activity also made an independent contribution to the models for plasma triglycerides (inversely) in females and HDL cholesterol and HDL cholesterol as a proportion of total cholesterol (positively) in males. The authors have demonstrated improved cardiovascular disease profiles associated with physical activity in Mauritians. The data suggest that much of the effect is modulated via an effect on insulin-glucose metabolism. Promotion of exercise should become an important strategy in the prevention of cardiovascular disease and glucose intolerance in this population.