REGIONAL BLOOD-TO-TISSUE TRANSPORT IN ETHYLNITROSOUREA-INDUCED BRAIN-TUMORS
REGIONAL BLOOD-TO-TISSUE TRANSPORT IN ETHYLNITROSOUREA-INDUCED BRAIN-TUMORS
复制标题
DOI：
10.1002/ana.410140207
复制
发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
FENSTERMACHER, JD
中科院分区：
文献类型：
--
作者：
BLASBERG, RG;KOBAYASHI, T;FENSTERMACHER, JD
用~(14)C标记的α-氨基异丁酸(AIB)和定量放射自显影测定了实验性脑肿瘤局部血液到组织的转运，以单向转运速率常数(K)表示。共观察9只大鼠，其中少突胶质细胞瘤16例，混合性胶质瘤4例，星形细胞瘤3例，弥漫性胶质瘤2例，间变性星形细胞瘤1例，室管膜瘤1例，恶性神经鞘瘤4例。所有胶质瘤分类的平均K值相似，平均为2.6。+-。0.4(平均值的标准误差)毫升.cntdo.Kg-1min-1，仅略高于非肿瘤性顶核(2.1ml.cntdot)。Kg~(-1)min~(-1))，结缔组织(0.9ml.cntdo.Kg-1.cntdo.Min-1)，以及对侧大脑半球的可比区域(1.3毫升.cntdot)。Kg-1.cntdo.Min-1)。K值在脑内胶质瘤中变化最小，仅2例与肿瘤细胞形态有一定的相关性。在一些(但不是全部)较大的胶质瘤中，血管增多，伴或不伴内皮细胞增殖，与K增加3-15倍相关。恶性神经鞘瘤的区域K值变化很大(4-207毫升.cntdot)。Kg-1.cntdo.Min-1)，一般与肿瘤的特定组织学特征无关，除非在某些血管增多的区域。估计颅内胶质瘤和恶性神经鞘瘤的AIB平均提取分数分别为0.01和0.2；非肿瘤性脑组织的平均提取分数为.apprx。0.003。
Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental brain tumors using .alpha.-aminoisobutyric acid (AIB) labeled with 14C and quantitative autoradiography. A total of 16 oligodendrogliomas, 4 mixed gliomas, 3 astrocytomas, 2 diffuse gliomatoses, 1 anaplastic astrocytoma, 1 ependymoma and 4 malignant schwannomas were studied in 9 rats. The mean K for all glioma classifications were similar, averaging 2.6 .+-. 0.4 (standard error of the mean) ml .cntdot. kg-1 min-1, and were only slightly higher than those for nontumorous parietal corex (2.1 ml .cntdot. kg-1 min-1), corpus callosum (0.9 ml .cntdot. kg-1 .cntdot. min-1), and a comparable region of brain tissue in the contralateral hemisphere (1.3 ml .cntdot. kg-1 .cntdot. min-1). Values of K varied minimally in the intracerebral gliomas and were marginally correlated with tumor cell morphology in only 2 tumors. In some (but not all) of the larger gliomas, increased vascularity, with or without endothelial proliferation, was associated with a 3- to 15-fold increase in K. Regional K values in malignant schwannomas were highly variable (4-207 ml .cntdot. kg-1 .cntdot. min-1) and generally were not correlated with specific histological features of the tumor, except in some regions with increased vascularity. Estimates of the average fractional extraction of AIB by the intracranial gliomas and malignant schwannomas were 0.01 and 0.2, respectively; average fractional extractions for nontumorous brain were .apprx. 0.003.