Identification and transmission of hepatitis B virus-related variants.
Identification and transmission of hepatitis B virus-related variants.
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乙型肝炎病毒相关变种的鉴定和传播。
DOI：
10.1073/pnas.83.17.6608
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发表时间：
1986
影响因子：
11.1
通讯作者：
Brechot,C
中科院分区：
文献类型：
--
作者：
Wands,JR;Fujita,YK;Isselbacher,KJ;Degott,C;Schellekens,H;Dazza,MC;Thiers,V;Tiollais,P;Brechot,C
我们已经鉴定出与B型肝炎病毒（HBV）共享表位的长潜伏期病毒因子。在黑猩猩感染性研究中，这些药物可能在肝脏中被识别，因为它们具有与HBV DNA互补的核酸序列;发现基因组大小为3.2个内切酶，与HBV相同。造成肝损伤，肝细胞内有抗原表达。黑猩猩事先免疫接种B型肝炎表面抗原并不能保护它们;相反，它们在感染后恢复后仍然对HBV易感。这些发现表明，这些与B型肝炎病毒相关的变异体在免疫学上似乎与HBV不同。
We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.